Anti-DIABLO

Anti-DIABLO
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
E-AB-64634.60 60 µl - -

7 - 16 Werktage*

117,00 €
E-AB-64634.120 120 µl - -

7 - 16 Werktage*

208,00 €
E-AB-64634.200 200 µl - -

7 - 16 Werktage*

363,00 €
 
This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded... mehr
Produktinformationen "Anti-DIABLO"
This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and allows activation of caspases by binding to inhibitor of apoptosis proteins. Overexpression of the encoded protein sensitizes tumor cells to apoptosis. A mutation in this gene is associated with young-adult onset of nonsyndromic deafness-64. Alternative splicing results in multiple transcript variants encoding different isoforms. Protein function: Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis- inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance. [The UniProt Consortium]
Schlagworte: Anti-SMAC, Anti-Smac, Anti-DIABLO, Anti-Diablo homolog, mitochondrial, Anti-Direct IAP-binding protein with low pI, Anti-Second mitochondria-derived activator of caspase, DIABLO Polyclonal Antibody
Hersteller: Elabscience
Hersteller-Nr: E-AB-64634-60µL

Eigenschaften

Anwendung: IF
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Reaktivität: Human
Immunogen: Recombinant protein of human DIABLO

Handhabung & Sicherheit

Lagerung: -20°C
Versand: -20°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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