Anti-DIABLO

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
E-AB-10598.20 20 µl - -

7 - 16 Werktage*

63,00 €
E-AB-10598.60 60 µl - -

7 - 16 Werktage*

119,00 €
E-AB-10598.120 120 µl - -

7 - 16 Werktage*

211,00 €
E-AB-10598.200 200 µl - -

7 - 16 Werktage*

367,00 €
 
This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded... mehr
Produktinformationen "Anti-DIABLO"
This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and it moderates the caspase inhibition of IAPs. Multiple polyadenylation sites have been found for this gene. Four alternatively spliced transcript variants have been described for this gene, with two of them encoding different isoforms and the other two probably not encoding a protein. Ubiquitously expressed with highest expression in testis. Expression is also high in heart, liver, kidney, spleen, prostate and ovary. Low in brain, lung, thymus and peripheral blood leukocytes. Isoform 3 is ubiquitously expressed. Protein function: Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis- inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance. [The UniProt Consortium]
Schlagworte: Anti-Smac, Anti-SMAC, Anti-DIABLO, Anti-Diablo homolog, mitochondrial, Anti-Direct IAP-binding protein with low pI, Anti-Second mitochondria-derived activator of caspase, DIABLO Polyclonal Antibody
Hersteller: Elabscience
Hersteller-Nr: E-AB-10598

Eigenschaften

Anwendung: WB, IHC, ELISA
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Reaktivität: Human, Mouse
Immunogen: Recombinant protein of human DIABLO
Format: Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: -20°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
Hier kriegen Sie ein Zertifikat
oder , um Analysenzertifikate anzufordern.
Bewertungen lesen, schreiben und diskutieren... mehr
Kundenbewertungen für "Anti-DIABLO"
Bewertung schreiben
oder , um eine Produktbewertung abzugeben.
Zuletzt angesehen