Anti-DDB1

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
A300-462A-T 20 µl (2 blots) -

3 - 9 Werktage*

131,00 €
A300-462A-M 100 µl (10 blots) -

3 - 9 Werktage*

313,00 €
A300-462A 100 µl (20 µg) -

3 - 9 Werktage*

465,00 €
 
Protein function: Required for DNA repair. Binds to DDB2 to form the UV- damaged DNA-binding... mehr
Produktinformationen "Anti-DDB1"
Protein function: Required for DNA repair. Binds to DDB2 to form the UV- damaged DNA-binding protein complex (the UV-DDB complex). The UV- DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the DCX E3 ubiquitin- protein ligase complex is determined by the variable substrate recognition component recruited by DDB1. DCX(DDB2) (also known as DDB1-CUL4-ROC1, CUL4-DDB-ROC1 and CUL4-DDB-RBX1) may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. DCX(DDB2) also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication. DCX(ERCC8) (the CSA complex) plays a role in transcription-coupled repair (TCR). May also play a role in ubiquitination of CDKN1B/p27kip when associated with CUL4 and SKP2. [The UniProt Consortium]
Schlagworte: Anti-XPCe, Anti-DDB1, Anti-DDBa, Anti-XAP1, Anti-XAP-1, Anti-XPE-BF, Anti-UV-DDB 1, Anti-DDB p127 subunit, Anti-XPE-binding factor, Anti-HBV X-associated protein 1, Anti-DNA damage-binding protein 1, Anti-DNA damage-binding protein a
Hersteller: Bethyl Laboratories
Hersteller-Nr: A300-462A

Eigenschaften

Anwendung: WB, IP, IHC
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Reaktivität: Human, Mouse (Erwartet: Rat, X. Laevis, Bovine, Orangutan)
Immunogen: synthetic peptide. The epitope recognized by A300-462A-T maps to a region between residue 1100 and the C-terminus (residue 1140) of human damage-specific DNA binding protein 1 using the numbering given in TrEMBL entry Q13289 (GeneID 1642).
Format: Antigen Affinity Purified

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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