Anti-Cytokeratin 4 (C-Term) Rabbit Monoclonal Antibody (Clone RM355)

Cytokeratin 4 is a type II epithelial intermediate filament protein. It is composed of a central rod containing four alpha-helical domains, which are important for self-assembly, and non-helical head and tail domains at the N- and C-termini, respectively. Cytokeratin 4 is expressed in mucosal stratified squamous epithelial cells, columnar luminal cells of the respiratory epithelium, and in non-stratified simple epithelial cells, with the highest expression in the esophagus and cornea. Cytokeratin 4 dimerizes with the type I epithelial intermediate filament protein cytokeratin 13, with the dimers then combining to form tetramers. Mice lacking Krt4, the gene encoding cytokeratin 4, have disruptions in the epithelial integrity of the esophagus, tongue, and cornea, including basal hyperplasia, lack of cell maturation, and hyperkeratosis. Mutations in KRT4 have been associated with white sponge nevus, a disorder characterized by thickened white, spongy plaques on the oral mucosa. Cayman's Cytokeratin 4 (C-Term) Rabbit Monoclonal Antibody (Clone RM355) can be used for immunohistochemistry (IHC) and Western blot applications.Synonyms: CK-4, Keratin-4, Keratin, Type II Cytoskeletal 4, KRT4. Immunogen: Peptide from the C-terminal region of human cytokeratin 4. Clone Designation: RM355. Formulation: (Request formulation change), 100 µl of protein A-affinity purified monoclonal antibody. Storage Buffer: PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide. Host: Rabbit. Isotype: IgG. Applications: IHC, WB. Cross Reactivity: (+) Cytokeratin 4.