Anti-CSN5 (IHC)

Anti-CSN5 (IHC)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
IHC-00362-T 10 µl (5+ slides) -

3 - 9 Werktage*

131,00 €
IHC-00362 100 µl (50+ slides) -

3 - 9 Werktage*

493,00 €
 
Protein function: Probable protease subunit of the COP9 signalosome complex (CSN), a complex... mehr
Produktinformationen "Anti-CSN5 (IHC)"
Protein function: Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex. Promotes the proteasomal degradation of BRSK2. [The UniProt Consortium]
Schlagworte: Anti-CSN5, Anti-SGN5, Anti-COPS5, EC=3.4.-.-, Anti-Signalosome subunit 5, Anti-COP9 signalosome complex subunit 5, Anti-Jun activation domain-binding protein 1
Hersteller: Bethyl Laboratories
Hersteller-Nr: IHC-00362-T

Eigenschaften

Anwendung: IHC
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Reaktivität: Human, Mouse (Erwartet: Rat, Zebrafish, X. Laevis, X. Tropicalis, Chicken, Turkey, Bovine, Dog, Horse, Rabbit, Guinea Pig, Swine, Panda, Orangutan, Rhesus Monkey, Chimpanzee, Giant Tiger Prawn, Spotted Green Pufferfish)
Immunogen: synthetic peptide. The epitope recognized by IHC-00362 maps to a region between residues 175 and 225 of human COP9 constitutive photomorphogenic homolog subunit 5 using the numbering given in entry NP_006828.2 (GeneID 10987).
Format: Antigen Affinity Purified

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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