Anti-COX-2 (Clone CX229)

Anti-COX-2 (Clone CX229)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
Cay160112-1 1 each -

6 - 10 Werktage*

422,00 €
 
Cyclooxygenase 2 (COX-2) is a bifunctional enzyme that exhibits both COX and peroxidase... mehr
Produktinformationen "Anti-COX-2 (Clone CX229)"
Cyclooxygenase 2 (COX-2) is a bifunctional enzyme that exhibits both COX and peroxidase activities and catalyzes the first step in the biosynthesis of prostaglandins, thromboxanes, and prostacyclins. The COX component converts arachidonic acid (Cay-90010, Cay-90010.1, Cay-10006607) to the hydroperoxy endoperoxide prostaglandin G2 (PGG2, Cay-17010), and the peroxidase component reduces the endoperoxide to the corresponding alcohol PGH2 (Cay-17020). COX2 expression is induced by a variety of stimuli, including phorbol esters, LPS, and cytokines and is responsible for the biosynthesis of PGs under acute inflammatory conditions. Thus, COX-2 has been the focus of attention for nonsteroidal anti-inflammatory drug (NSAID) development. Cayman's COX-2 (human) Monoclonal Antibody (Clone CX229) can be used for immunohistochemistry (IHC) and Western blot (WB) applications. The antibody recognizes a unique C-terminal region of COX-2 that is not present in COX-1, specifically detecting COX-2 ~70 kDa from human and ovine samples.Synonyms: Cyclooxygenase 2, PGHS-2, Prostaglandin H Synthase 2. Immunogen: Synthetic peptide from the C-terminal region of human protein COX-2. Clone Designation: CX229. Formulation: (Request formulation change), 50 µg of protein G-purified monoclonal antibody. Storage Buffer: PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide. Host: Mouse. Isotype: IgG1. Applications: IHC, WB. Cross Reactivity: (-) COX-1.
Schlagworte: Cyclooxygenase 2, PGHS-2, Prostaglandin H Synthase 2
Hersteller: Cayman Chemical
Hersteller-Nr: 160112

Eigenschaften

Anwendung: IHC, WB
Antikörper-Typ: Monoclonal
Klon: CX229
Konjugat: No
Wirt: Mouse
Spezies-Reaktivität: human, ovine, monkey (Erwartet: bovine, canine)
Immunogen: Synthetic peptide from the C-terminal region of human protein COX-2
Format: Purified

Datenbank Information

KEGG ID : K11987 | Passende Produkte
UniProt ID : P35354 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: -20°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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