Anti-COMP

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
E-AB-14886.20 20 µl -

7 - 16 Werktage*

71,00 €
E-AB-14886.60 60 µl -

7 - 16 Werktage*

143,00 €
E-AB-14886.120 120 µl -

7 - 16 Werktage*

238,00 €
E-AB-14886.200 200 µl -

7 - 16 Werktage*

396,00 €
 
The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It... mehr
Produktinformationen "Anti-COMP"
The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Mutations can cause the osteochondrodysplasias pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED). Protein function: May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7. [The UniProt Consortium]
Schlagworte: Anti-COMP, Anti-TSP5, Anti-Thrombospondin-5, Anti-Cartilage oligomeric matrix protein, COMP Polyclonal Antibody
Hersteller: Elabscience
Hersteller-Nr: E-AB-14886

Eigenschaften

Anwendung: IHC, ELISA
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human, mouse, rat
Immunogen: Recombinant protein of human COMP
Format: Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: 4°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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