Anti-CD61 (human) (APC Conjugated), clone VI-PL2

Anti-CD61 (human) (APC Conjugated), clone VI-PL2
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
E-AB-F1166E.20 20 tests - -

7 - 16 Werktage*

82,00 €
E-AB-F1166E.50 50 tests - -

7 - 16 Werktage*

132,00 €
E-AB-F1166E.100 100 tests - -

7 - 16 Werktage*

200,00 €
E-AB-F1166E.200 200 tests - -

7 - 16 Werktage*

300,00 €
 
CD61, also known as integrin beta3 and glycoprotein IIIa (gpIIIa), is a 90 kD type I integral... mehr
Produktinformationen "Anti-CD61 (human) (APC Conjugated), clone VI-PL2"
CD61, also known as integrin beta3 and glycoprotein IIIa (gpIIIa), is a 90 kD type I integral transmembrane glycoprotein. It is a member of the integrin family, associating with platelet gpIIb (CD41) to form CD41/CD61 complex and with integrin alphaV (CD51) to form alphaV/beta3 (CD51/CD61) integrin. CD41/CD61 is expressed on platelets and megakaryocytes, and plays a role in platelet activation and aggregation through interaction with fibrinogen, fibronectin, vWF, and other RGD-containing adhesion molecules. CD51/CD61 is expressed on platelets, osteoclasts, fibroblasts, macrophages, and some tumor cells involved in tumor metastasis, and in adenovirus infection through binding to RGD motif in extracellular matrix proteins. Protein function: Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha- IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets. ITGAV:ITGB3 binds to fractalkine (CX3CL1) and acts as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415, PubMed:24789099). ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling (PubMed:18441324). ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling (PubMed:28302677). ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:19578119). ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling (PubMed:29030430). ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGAV:ITGB3 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887). [The UniProt Consortium]
Schlagworte: Anti-CD61, Anti-GP3A, Anti-ITGB3, Anti-GPIIIa, Anti-Integrin beta-3, Anti-Platelet membrane glycoprotein IIIa, Anti-Human CD61 Monoclonal Antibody(APC Conjugated)
Hersteller: Elabscience
Hersteller-Nr: E-AB-F1166E

Eigenschaften

Anwendung: FC
Antikörper-Typ: Monoclonal
Klon: VI-PL2
Konjugat: APC
Wirt: Mouse
Reaktivität: Human

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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