Anti-CD61 (APC), clone CLB-thromb/1, C17

Anti-CD61 (APC), clone CLB-thromb/1, C17
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
G-AGIM0480.100 100 µl -

9 - 20 Werktage*

152,00 €
 
Protein function: Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin,... mehr
Produktinformationen "Anti-CD61 (APC), clone CLB-thromb/1, C17"
Protein function: Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha- IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets. ITGAV:ITGB3 binds to fractalkine (CX3CL1) and acts as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415, PubMed:24789099). ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling (PubMed:18441324). ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling (PubMed:28302677). ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:19578119). ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling (PubMed:29030430). ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGAV:ITGB3 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887). [The UniProt Consortium]
Schlagworte: Anti-CD61, Anti-GP3A, Anti-ITGB3, Anti-GPIIIa, Anti-Integrin beta-3, Anti-Platelet membrane glycoprotein IIIa, CD61 monoclonal antibody (APC) (AGIM0480)
Hersteller: Assay Genie
Hersteller-Nr: AGIM0480

Eigenschaften

Anwendung: FC, IF
Antikörper-Typ: Monoclonal
Klon: CLB-thromb/1, C17
Konjugat: APC
Wirt: Mouse
Reaktivität: Human

Handhabung & Sicherheit

Lagerung: vT
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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