Anti-CD3 Monoclonal Antibody (Clone:MEM-57)-FITC Conjugated

Anti-CD3 Monoclonal Antibody (Clone:MEM-57)-FITC Conjugated
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ABE-30-1935-100 100 tests -

3 - 11 Werktage*

653,00 €
 
CD3 complex is crucial in transducing antigen-recognition signals into the cytoplasm of T cells... mehr
Produktinformationen "Anti-CD3 Monoclonal Antibody (Clone:MEM-57)-FITC Conjugated"
CD3 complex is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. Protein function: Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098). In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down- regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region (PubMed:10384095, PubMed:26507128). [The UniProt Consortium]
Schlagworte: Anti-T3E, Anti-CD3E, Anti-CD3e, Anti-T-cell surface glycoprotein CD3 epsilon chain, Anti-T-cell surface antigen T3/Leu-4 epsilon chain, Anti-CD3 Monoclonal Antibody (Clone:MEM-57)-FITC Conjugated
Hersteller: Abeomics
Hersteller-Nr: 30-1935

Eigenschaften

Anwendung: FC, IP, FA
Antikörper-Typ: Monoclonal
Klon: MEM-57
Konjugat: FITC
Wirt: Mouse
Spezies-Reaktivität: human
Immunogen: Human thymocytes and T lymphocytes.

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
Hier kriegen Sie ein Zertifikat
oder , um Analysenzertifikate anzufordern.
Bewertungen lesen, schreiben und diskutieren... mehr
Kundenbewertungen für "Anti-CD3 Monoclonal Antibody (Clone:MEM-57)-FITC Conjugated"
Bewertung schreiben
oder , um eine Produktbewertung abzugeben.
Zuletzt angesehen