Anti-CCDC88A

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
E-AB-13059.20 20 µl -

7 - 16 Werktage*

71,00 €
E-AB-13059.60 60 µl -

7 - 16 Werktage*

143,00 €
E-AB-13059.120 120 µl -

7 - 16 Werktage*

238,00 €
E-AB-13059.200 200 µl -

7 - 16 Werktage*

396,00 €
 
This gene encodes a member of the Girdin family of coiled-coil domain containing proteins. The... mehr
Produktinformationen "Anti-CCDC88A"
This gene encodes a member of the Girdin family of coiled-coil domain containing proteins. The encoded protein is an actin-binding protein that is activated by the serine/threonine kinase Akt and plays a role in cytoskeleton remodeling and cell migration. The encoded protein also enhances Akt signaling by mediating phosphoinositide 3-kinase (PI3K)-dependent activation of Akt by growth factor receptor tyrosine kinases and G protein-coupled receptors. Increased expression of this gene and phosphorylation of the encoded protein may play a role in cancer metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Protein function: Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Enhances phosphoinositide 3-kinase (PI3K)- dependent phosphorylation and kinase activity of AKT1/PKB, but does not possess kinase activity itself. Phosphorylation of AKT1/PKB thereby induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation. Essential for the integrity of the actin cytoskeleton and for cell migration (PubMed:16139227). Required for formation of actin stress fibers and lamellipodia (PubMed:15882442). May be involved in membrane sorting in the early endosome (PubMed:15882442). Plays a role in ciliogenesis and cilium morphology and positioning and this may partly be through regulation of the localization of scaffolding protein CROCC/Rootletin (PubMed:27623382). [The UniProt Consortium]
Schlagworte: Anti-GIV, Anti-APE, Anti-HkRP1, Anti-Girdin, Anti-CCDC88A, Anti-Hook-related protein 1, Anti-Girders of actin filament, Anti-Akt phosphorylation enhancer, Anti-Coiled-coil domain-containing protein 88A, Anti-G alpha-interacting vesicle-associated protein,
Hersteller: Elabscience
Hersteller-Nr: E-AB-13059

Eigenschaften

Anwendung: IHC, ELISA
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human, mouse
Immunogen: Synthetic peptide of human CCDC88A
Format: Purified

Datenbank Information

UniProt ID : Q3V6T2 | Passende Produkte
Gene ID GeneID 55704 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: 4°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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