Anti-Caspase-3

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
E-AB-66940.60 60 µl -

7 - 16 Werktage*

198,00 €
E-AB-66940.120 120 µl -

7 - 16 Werktage*

317,00 €
E-AB-66940.200 200 µl -

7 - 16 Werktage*

525,00 €
 
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase)... mehr
Produktinformationen "Anti-Caspase-3"
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. Protein function: Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-, -Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage. [The UniProt Consortium]
Schlagworte: Anti-CASP3, Anti-CPP32, EC=3.4.22.56, Caspase-3 Polyclonal Antibody
Hersteller: Elabscience
Hersteller-Nr: E-AB-66940

Eigenschaften

Anwendung: WB, IHC, IF
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human, mouse, rat
Immunogen: Recombinant protein of human Caspase-3.

Handhabung & Sicherheit

Lagerung: -20°C
Versand: 4°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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