Anti-CASP1

Anti-CASP1
Anti-CASP1
   
NEU
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ATA-HPA003056.25 25 µl -

Fragen Sie uns nach der Lieferzeit

156,00 €
ATA-HPA003056.100 100 µl -

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363,00 €
 
Protein function: Thiol protease involved in a variety of inflammatory processes by... mehr
Produktinformationen "Anti-CASP1"
Protein function: Thiol protease involved in a variety of inflammatory processes by proteolytically cleaving other proteins, such as the precursors of the inflammatory cytokines interleukin-1 beta (IL1B) and interleukin 18 (IL18) as well as the pyroptosis inducer Gasdermin-D (GSDMD), into active mature peptides (PubMed:15326478, PubMed:1574116, PubMed:7876192, PubMed:15498465, PubMed:26375003). Plays a key role in cell immunity as an inflammatory response initiator: once activated through formation of an inflammasome complex, it initiates a proinflammatory response through the cleavage of the two inflammatory cytokines IL1B and IL18, releasing the mature cytokines which are involved in a variety of inflammatory processes (PubMed:1574116, PubMed:7876192, PubMed:15498465, PubMed:15326478). Cleaves a tetrapeptide after an Asp residue at position P1 (PubMed:1574116, PubMed:7876192, PubMed:15498465). Also initiates pyroptosis, a programmed lytic cell death pathway, through cleavage of GSDMD (PubMed:26375003). In contrast to cleavage of interleukins IL1B and IL1B, recognition and cleavage of GSDMD is not strictly dependent on the consensus cleavage site but depends on an exosite interface on CASP1 that recognizes and binds the Gasdermin-D, C-terminal (GSDMD-CT) part (PubMed:32109412, PubMed:32553275). Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive (PubMed:28314590). In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracellularly (PubMed:20197547). [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 72% and to rat: 75%
Schlagworte: Anti-IL1BC, Anti-CASP1
Hersteller: Atlas Antibodies
Hersteller-Nr: HPA003056

Eigenschaften

Anwendung: IHC, WB
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Reaktivität: Human
Immunogen: Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: PDILQLNAIF NMLNTKNCPS LKDKPKVIII QACRGDSPGV VWFKDSVGVS GNLSLPTTEE FEDDAIKKAH IEKDFIAFCS STPDNVSWRH PTMGSVFIGR LIEHMQEYAC SCDVEEIFRK VRFSFEQPDG RAQMPTTERV TLTRCFYLFP GH (ATA-APrEST86240)

Datenbank Information

KEGG ID : K01370 | Passende Produkte
UniProt ID : P29466 | Passende Produkte
Gene ID : GeneID 834 | Passende Produkte
Protein Atlas Nr. : ENSG00000137752

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +20°C (International: +20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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