Anti-Cardif (human), clone Adri-1

Anti-Cardif (human), clone Adri-1
%
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Rabatt Preis
AG-20B-0004-C100 100 µg -

3 - 9 Werktage*

10 %
407,00 €
366,30 €
 
Recognizes human Cardif. Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. RIG-I... mehr
Produktinformationen "Anti-Cardif (human), clone Adri-1"
Recognizes human Cardif. Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. RIG-I (retinoic acid-inducible gene I, Ddx58) and MDA5 (melanoma differentiation-associated gene 5, also known as Ifih1 or Helicard) are proteins that sense viral replication intermediates, such as double-stranded RNA and triggers the host antiviral programs. These molecules signal the downstream activation of NF-kappaB and IFN regulatory factor (IRF) -3, which coordinately regulate the expression of type-I interferons. Cardif (also called VISA/IPS-1/MAVS) is a new CARD (caspase activation and recruitment domain)-containing adaptor protein that interacts with the CARD domain of RIG-I and MDA5, leading to the activation of NF-kappaB and IRF3. Cardif is located to the mitochondrial outer membrane. Removal of the mitochondrial-targeting domain of cardif abolishes its ability to induce IFNs. Cardif is cleaved and inactivated by NS3-4A, a serine protease from hepatitis C virus known to block interferon-beta production.
Schlagworte: CARD Adapter Inducing Interferon-beta, IPS-1, Interferon-beta Promoter Stimulator Protein 1, MAVS, Mitochondrial Antiviral Signaling Protein, VISA, Virus-induced Signaling Adapter
Hersteller: AdipoGen Life Sciences
Hersteller-Nr: AG-20B-0004

Eigenschaften

Anwendung: ICC, IHC, IP, WB
Antikörper-Typ: Monoclonal
Klon: Adri-1
Konjugat: No
Wirt: Mouse
Spezies-Reaktivität: human
Immunogen: Recombinant human Cardif (aa 160-450).
Format: Purified

Datenbank Information

KEGG ID : K12648 | Passende Produkte
UniProt ID : Q7Z434 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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