Anti-CACNA1C

Anti-CACNA1C
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
NSJ-R32224 100 µg - -

3 - 10 Werktage

503,00 €
 
0.5mg/ml if reconstituted with 0.2ml sterile DI water. CACNA1C is also known as TS, LQT8, CACH2,... mehr
Produktinformationen "Anti-CACNA1C"
0.5mg/ml if reconstituted with 0.2ml sterile DI water. CACNA1C is also known as TS, LQT8, CACH2, CACN2, CaV1.2, CCHL1A1, CACNL1A1. It is mapped to 12p13.3. This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta and beta subunits in a 1:1:1 ratio. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins. Some of the predicted proteins may not produce functional ion channel subunits. Protein function: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death (PubMed:29078335). The isoform alpha-1C gives rise to L-type calcium currents. Long- lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin- IIIA (omega-Aga-IIIA). They are however insensitive to omega- conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga- IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. The various isoforms display marked differences in the sensitivity to DHP compounds. Binding of calmodulin or CABP1 at the same regulatory sites results in opposite effects on the channel function. STAC3 strongly decreases the rate of channel inactivation (PubMed:29078335). [The UniProt Consortium]
Schlagworte: Anti-CACH2, Anti-CACNA1C, Anti-Voltage-gated calcium channel subunit alpha Cav1.2, Anti-Voltage-dependent L-type calcium channel subunit alpha-1C, Anti-Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle, CACNA1C Antibody
Hersteller-Nr: R32224

Eigenschaften

Anwendung: WB
Antikörper-Typ: Polyclonal
Wirt: Rabbit
Reaktivität: Mouse, Rat
Immunogen: Amino acids 1933-2026 of human CACNA1C were used as the immunogen for the CACNA1C antibody.
Format: Purified

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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