Anti-C1QB / Complement C1q B-Chain, clone C1QB/2961

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
NSJ-V8087-20UG 20 µg - -

3 - 10 Werktage*

291,00 €
NSJ-V8087-100UG 100 µg - -

3 - 10 Werktage*

664,00 €
 
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. C1q, a subcomponent of the... mehr
Produktinformationen "Anti-C1QB / Complement C1q B-Chain, clone C1QB/2961"
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. C1q, a subcomponent of the classical complement pathway, is composed of nine subunits that mediate classical complement activation and thereby play an important role in the immune response. Six of these subunits are disulfide-linked dimers of chains A and B, while three of these subunits, designated C1q-A through C1q-C, are disulfide-linked dimers of chain C. Each chain contains an N-terminal collagen-like region and a C-terminal C1q globular domain. The presence of receptors for C1q on effector cells modulates its activity, which may be antibody-dependent or independent. Macrophages are the primary source of C1q, while anti-inflammatory drugs as well as cytokines differentially regulate expression of the mRNA as well as the protein. C1q deficiency is associated with lupus erythematosus and glomerulonephritis. Protein function: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. [The UniProt Consortium]
Schlagworte: Anti-C1QB, Anti-Complement C1q subcomponent subunit B, C1QB Antibody / Complement C1q B-Chain
Hersteller: NSJ Bioreagents
Hersteller-Nr: V8087

Eigenschaften

Anwendung: IHC (paraffin)
Antikörper-Typ: Monoclonal
Klon: C1QB/2961
Konjugat: No
Wirt: Mouse
Reaktivität: Human
Immunogen: A recombinant human partial protein (amino acids 41-188)
Format: Purified

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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