Anti-BubR1 (IHC)

Anti-BubR1 (IHC)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
IHC-00498-T 10 µl (2500 ng) -

2 - 8 Werktage*

164,00 €
IHC-00498 100 µl (25 µg) -

2 - 8 Werktage*

623,00 €
 
Protein function: Essential component of the mitotic checkpoint. Required for normal mitosis... mehr
Produktinformationen "Anti-BubR1 (IHC)"
Protein function: Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. [The UniProt Consortium]
Schlagworte: Anti-BUB1B, Anti-BUBR1, Anti-hBUBR1, EC=2.7.11.1, Anti-Protein SSK1, Anti-Mitotic checkpoint kinase MAD3L, Anti-MAD3/BUB1-related protein kinase, Anti-Mitotic checkpoint serine/threonine-protein kinase BUB1 beta
Hersteller: Bethyl Laboratories
Hersteller-Nr: IHC-00498

Eigenschaften

Anwendung: IHC
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human (Erwartet: orangutan, rhesus monkey, gorilla, chimpanzee, crab-eating macaque)
Immunogen: synthetic peptide. The epitope recognized by IHC-00498 maps to a region between residue 1 and 50 of human budding uninhibited by benzimidazoles 1 homolog beta using the numbering given in entry NP_001202.3 (GeneID 701).
Format: Antigen Affinity Purified

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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