Anti-BIRC2

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ATA-HPA005513.25 25 µl -

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156,00 €
ATA-HPA005513.100 100 µl -

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363,00 €
 
Protein function: Multi-functional protein which regulates not only caspases and apoptosis, but... mehr
Produktinformationen "Anti-BIRC2"
Protein function: Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non- canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase- independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 69% and to rat: 66%
Schlagworte: Anti-API1, Anti-hIAP2, Anti-BIRC2, Anti-hIAP-2, Anti-C-IAP1, Anti-IAP homolog B, Anti-RING finger protein 48, Anti-Inhibitor of apoptosis protein 2, Anti-Cellular inhibitor of apoptosis 1, Anti-TNFR2-TRAF-signaling complex protein 2
Hersteller: Atlas Antibodies
Hersteller-Nr: HPA005513

Eigenschaften

Anwendung: IHC, WB
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Reaktivität: Human, Rat
Immunogen: Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: NWKLGDSPIQ KHKQLYPSCS FIQNLVSASL GSTSKNTSPM RNSFAHSLSP TLEHSSLFSG SYSSLSPNPL NSRAVEDISS SRTNPYSYAM STEEARFLTY HMWPLTFLSP SELARAGF (ATA-APrEST86198)

Datenbank Information

KEGG ID : K16060 | Passende Produkte
UniProt ID : Q13490 | Passende Produkte
Gene ID : GeneID 329 | Passende Produkte
Protein Atlas Nr. : ENSG00000110330

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +20°C (International: +20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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