Anti-BHLHE41 [Rabbit] (CAB10555)

Anti-BHLHE41 [Rabbit] (CAB10555)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
G-CAB10555.50 50 µl -

9 - 20 Werktage*

261,00 €
 
BHLHE41 Rabbit Polyclonal Antibody from Assay Genie with reactivity against Human, Mouse, Rat and... mehr
Produktinformationen "Anti-BHLHE41 [Rabbit] (CAB10555)"
BHLHE41 Rabbit Polyclonal Antibody from Assay Genie with reactivity against Human, Mouse, Rat and for use in WB applications.BHLHE41 Rabbit Polyclonal Antibody is an IgG isotype antibody and produced in Rabbit and purified by Affinity purification from Assay Genie.. Protein function: Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes (PubMed:11278948, PubMed:14672706, PubMed:15193144, PubMed:15560782, PubMed:18411297, PubMed:19786558, PubMed:25083013). Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes (PubMed:25083013). Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA/B/G, NR1H3/LXRA, NR1H4 and VDR transactivation activity. Inhibits HNF1A-mediated transactivation of CYP1A2, CYP2E1 AND CYP3A11. [The UniProt Consortium]
Schlagworte: Anti-hDEC2, Anti-BHLHB3, Anti-bHLHb3, Anti-SHARP-1, Anti-bHLHe41, Anti-Class B basic helix-loop-helix protein 3, Anti-Class E basic helix-loop-helix protein 41, Anti-Enhancer-of-split and hairy-related protein 1
Hersteller: Assay Genie
Hersteller-Nr: CAB10555

Eigenschaften

Anwendung: WB
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Reaktivität: Human, Mouse, Rat
Immunogen: Recombinant Protein

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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