Anti-BCL10

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
E-AB-60188.60 60 µl -

7 - 16 Werktage*

218,00 €
E-AB-60188.120 120 µl -

7 - 16 Werktage*

356,00 €
E-AB-60188.200 200 µl -

7 - 16 Werktage*

574,00 €
 
This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue... mehr
Produktinformationen "Anti-BCL10"
This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants. Protein function: Involved in adaptive immune response (PubMed:25365219). Promotes apoptosis, pro-caspase-9 maturation and activation of NF- kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1 (PubMed:18264101). [The UniProt Consortium]
Schlagworte: Anti-mE10, Anti-BCL10, Anti-CIPER, Anti-hCLAP, Anti-c-E10, Anti-Bcl-10, Anti-cCARMEN, Anti-Cellular-E10, Anti-B-cell CLL/lymphoma 10, Anti-CARD-like apoptotic protein, Anti-B-cell lymphoma/leukemia 10, Anti-Cellular homolog of vCARMEN, BCL10 Polyclonal An
Hersteller: Elabscience
Hersteller-Nr: E-AB-60188

Eigenschaften

Anwendung: WB
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human
Immunogen: Recombinant protein of human BCL10

Handhabung & Sicherheit

Lagerung: -20°C
Versand: 4°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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