Anti-Bad

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
NSJ-F42825-0.08ML 80 µl - -

3 - 10 Werktage*

326,00 €
NSJ-F42825-0.4ML 400 µl - -

3 - 10 Werktage*

702,00 €
 
In 1X PBS, pH 7.4, with 0.09% sodium azide. Apoptosis or programmed cell death is a physiological... mehr
Produktinformationen "Anti-Bad"
In 1X PBS, pH 7.4, with 0.09% sodium azide. Apoptosis or programmed cell death is a physiological cellular process characterized by cell shrinkage, membrane blebbing, DNA fragmentation, and release of Cytochrome C from the mitochondria. It is utilized by the organism to get rid of unwanted cells, which is critical for normal development and homeostasis of an organism. Disregulation of normal apoptosis process have been implicated in a variety of diseases, including cancer, autoimmune diseases, viral infections, etc. Programmed cell death occurs through complex cascades of cell signaling in which Bcl-2 family members, among others, play an important role.The Bcl-2 family of proteins regulate apoptosis as well as execute death signals at the mitochondrion. Members of this family include both pro- and anti-apoptotic proteins that hare homology sequences called Bcl-2 Homology domains (BH1-4) which mediate dimmer formation. The BH3 proteins, such as BID, NOXA, PUMA, BIK, BIM and BAD are all pro-apoptotic and share sequence homology within the amphipathic alpha-helical BH3 region, which is required for their apoptotic function. They may trigger release of death-inducing molecules such as Cytochrome C, Smac, and endonuclease G. Anti-apoptotic family members, including Bcl-2 and Bcl-XL, play inhibitory roles. Bcl-2 family proteins may form homodimers or heterodimers between pro- and anti-apoptotic members, the ratios of which determine the cell fate. Protein function: Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2. Appears to act as a link between growth factor receptor signaling and the apoptotic pathways. [The UniProt Consortium]
Schlagworte: Anti-BAD, Anti-BBC6, Anti-Bcl2-L-8, Anti-Bcl-2-like protein 8, Anti-Bcl-2-binding component 6, Anti-Bcl2 antagonist of cell death, Anti-Bcl2-associated agonist of cell death, Anti-Bcl-xL/Bcl-2-associated death promoter, Bad Antibody
Hersteller: NSJ Bioreagents
Hersteller-Nr: F42825

Eigenschaften

Anwendung: WB, IHC, FC, ELISA
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human, mouse
Immunogen: A portion of amino acids 92-127 from the human protein was used as the immunogen for this Bad antibody.
Format: Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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