Anti-B-RAF Rabbit

Anti-B-RAF Rabbit
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
Cay32251-100 100 µl -

6 - 10 Werktage*

480,00 €
 
Rapidly accelerated fibrosarcoma (Raf) kinase is a serine/threonine kinase and component of the... mehr
Produktinformationen "Anti-B-RAF Rabbit"
Rapidly accelerated fibrosarcoma (Raf) kinase is a serine/threonine kinase and component of the MAPK/ERK signaling pathway. Upon activation by upstream RAS signaling, Raf dimerizes and phosphorylates MEK1 leading to activation of transcription factors for cell growth, proliferation, and survival. Raf exists as three isoforms, A-RAF, B-RAF, and C-RAF, that all consist of three conserved regions (CRs) with domain-specific functions. CR1 contains a cysteine-rich domain and a RAS-binding domain, CR2 is essential for negative regulation through inhibition of phosphorylation sites, and CR3 is the kinase domain. B-RAF is the most prominent isoform, expressed in most tissues, and localized to the cytosol. Activating mutations in B-RAF have been found in various cancers, including melanoma and non-small cell lung cancer (NSCLC), as well as in patients with Langerhans cell histiocytosis. Cayman's B-RAF Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.Synonyms: B-RAF Proto-oncogene, Proto-oncogene B-RAF, RAFB1, Serine/Threonine Kinase, V-Raf Murine Sarcoma Viral Oncogene Homolog B. Immunogen: Peptide corresponding to a region near the N-terminus of human B-RAF. Clone Designation: RM308. Formulation: (Request formulation change), 100 µl of protein A-affinity purified monoclonal antibody. Storage Buffer: PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide. Host: Rabbit. Isotype: IgG. Applications: IHC, WB. Cross Reactivity: (+) B-RAF.
Schlagworte: B-RAF Proto-oncogene, Proto-oncogene B-RAF, RAFB1, Serine/Threonine Kinase, V-Raf Murine Sarcoma Viral Oncogene Homolog B
Hersteller: Cayman Chemical
Hersteller-Nr: 32251

Eigenschaften

Anwendung: IHC, WB
Antikörper-Typ: Monoclonal
Klon: RM308
Konjugat: No
Wirt: Rabbit
Immunogen: Peptide corresponding to a region near the N-terminus of human B-RAF
Format: Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: -20°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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