Anti-Aurora A, clone 1A14

Anti-Aurora A, clone 1A14
Aktion:

Gratis WB-Box zu jeder Arigo-Bestellung. 

*1
*1 Angebot gültig bis zum 30.04.2019
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ARG10697.50 50 µl - -

6 - 14 Werktage

439,00 €
 
Protein function: Mitotic serine/threonine kinase that contributes to the regulation of cell... mehr
Produktinformationen "Anti-Aurora A, clone 1A14"
Protein function: Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis. [The UniProt Consortium]
Schlagworte: Anti-AIK, Anti-AURKA, Anti-hARK1, Anti-ARK-1, Anti-Aurora 2, EC=2.7.11.1, Anti-Aurora kinase A, Anti-Aurora-related kinase 1, Anti-Aurora/IPL1-related kinase 1, Anti-Breast tumor-amplified kinase, Anti-Serine/threonine-protein kinase 6
Hersteller-Nr: ARG10697050

Eigenschaften

Anwendung: WB, ICC, IF, IHC (frozen)
Antikörper-Typ: Monoclonal
Klon: 1A14
Wirt: Mouse
Reaktivität: Human
Immunogen: Full length recombinant Human protein  aurora A expressed in and purified from E. coli
Format: Affinity Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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