Anti-ATXN7, ID (ATXN7, SCA7, Ataxin-7, Spinocerebellar ataxia type 7 protein) (Azide free) (APC)

Anti-ATXN7, ID (ATXN7, SCA7, Ataxin-7, Spinocerebellar ataxia type 7 protein) (Azide free) (APC)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
032320-APC.200 200 µl - -

1 - 19 Werktage

696,00 €
 
The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative... mehr
Produktinformationen "Anti-ATXN7, ID (ATXN7, SCA7, Ataxin-7, Spinocerebellar ataxia type 7 protein) (Azide free) (APC)"
The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the 'pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. This locus has been mapped to chromosome 3, and it has been determined that the diseased allele associated with spinocerebellar ataxia-7 contains 38-130 CAG repeats (near the N-terminus), compared to 7-17 in the normal allele. The encoded protein is a component of the SPT3/TAF9/GCN5 acetyltransferase (STAGA) and TBP-free TAF-containing (TFTC) chromatin remodeling complexes, and it thus plays a role in transcriptional regulation. Alternative splicing results in multiple transcript variants. Applications: Suitable for use in Western Blot, FLISA, Recommended Dilution: FLISA: 1:1,000, Western Blot: 1:100-500, Storage and Stability: Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap., , Note: Applications are based on unconjugated antibody.
Hersteller: United States Biological
Hersteller-Nr: 032320-APC

Eigenschaften

Anwendung: FLISA, WB
Antikörper-Typ: Polyclonal
Konjugat: APC
Wirt: Rabbit
Reaktivität: Human
Immunogen: ATXN7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 353-381 amino acids from the Central region of human ATXN7.
Format: Affinity Purified

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
Hier kriegen Sie ein Zertifikat
oder , um Analysenzertifikate anzufordern.
Bewertungen lesen, schreiben und diskutieren... mehr
Kundenbewertungen für "Anti-ATXN7, ID (ATXN7, SCA7, Ataxin-7, Spinocerebellar ataxia type 7 protein) (Azide free) (APC)"
Bewertung schreiben
oder , um eine Produktbewertung abzugeben.
Zuletzt angesehen