Anti-ATG7

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
E-AB-60098.60 60 µl -

7 - 16 Werktage*

198,00 €
E-AB-60098.120 120 µl -

7 - 16 Werktage*

317,00 €
E-AB-60098.200 200 µl -

7 - 16 Werktage*

525,00 €
 
This gene encodes an E1-like activating enzyme that is essential for autophagy and cytoplasmic to... mehr
Produktinformationen "Anti-ATG7"
This gene encodes an E1-like activating enzyme that is essential for autophagy and cytoplasmic to vacuole transport. The encoded protein is also thought to modulate p53-dependent cell cycle pathways during prolonged metabolic stress. It has been associated with multiple functions, including axon membrane trafficking, axonal homeostasis, mitophagy, adipose differentiation, and hematopoietic stem cell maintenance. Alternative splicing results in multiple transcript variants. Protein function: E1-like activating enzyme involved in the 2 ubiquitin- like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Plays also a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation. Plays a role in regulating the liver clock and glucose metabolism by mediating the autophagic degradation of CRY1 (clock repressor) in a time-dependent manner. [The UniProt Consortium]
Schlagworte: Anti-ATG7, Anti-hAGP7, Anti-APG7L, Anti-APG7-like, Anti-Autophagy-related protein 7, Anti-ATG12-activating enzyme E1 ATG7, Anti-Ubiquitin-activating enzyme E1-like protein, Anti-Ubiquitin-like modifier-activating enzyme ATG7, ATG7 Polyclonal Antibody
Hersteller: Elabscience
Hersteller-Nr: E-AB-60098

Eigenschaften

Anwendung: WB, IHC
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human, mouse, rat
Immunogen: Recombinant protein of human ATG7

Handhabung & Sicherheit

Lagerung: -20°C
Versand: 4°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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