Anti-ATG5, clone ATG5/2101

Anti-ATG5, clone ATG5/2101
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
NSJ-V3951-20UG 20 µg - -

3 - 10 Werktage*

332,00 €
NSJ-V3951-100UG 100 µg - -

3 - 10 Werktage*

752,00 €
 
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide. The protein encoded... mehr
Produktinformationen "Anti-ATG5, clone ATG5/2101"
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide. The protein encoded by this gene, in combination with autophagy protein 12, functions as an E1-like activating enzyme in a ubiquitin-like conjugating system. The encoded protein is involved in several cellular processes, including autophagic vesicle formation, mitochondrial quality control after oxidative damage, negative regulation of the innate antiviral immune response, lymphocyte development and proliferation, MHC II antigen presentation, adipocyte differentiation, and apoptosis. The ATG5 protein is essential for autophagy, a process that is usually beneficial for cells to self-degrade their own components when they are no longer useful. Protein function: Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway. [The UniProt Consortium]
Schlagworte: Anti-ATG5, Anti-APG5L, Anti-APG5-like, Anti-Autophagy protein 5, Anti-Apoptosis-specific protein, ATG5 Antibody
Hersteller: NSJ Bioreagents
Hersteller-Nr: V3951

Eigenschaften

Anwendung: WB, IHC (paraffin), ELISA
Antikörper-Typ: Monoclonal
Klon: ATG5/2101
Konjugat: No
Wirt: Mouse
Spezies-Reaktivität: human
Immunogen: A portion of of amino acids 1-119 from the human protein
Format: Purified

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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