Anti-ATG3

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
E-AB-14582.20 20 µl - -

7 - 16 Werktage

63,00 €
E-AB-14582.60 60 µl - -

7 - 16 Werktage

119,00 €
E-AB-14582.120 120 µl - -

7 - 16 Werktage

211,00 €
E-AB-14582.200 200 µl - -

7 - 16 Werktage

367,00 €
 
This gene encodes a ubiquitin-like-conjugating enzyme and is a component of ubiquitination-like... mehr
Produktinformationen "Anti-ATG3"
This gene encodes a ubiquitin-like-conjugating enzyme and is a component of ubiquitination-like systems involved in autophagy, the process of degradation, turnover and recycling of cytoplasmic constituents in eukaryotic cells. This protein is known to play a role in regulation of autophagy during cell death. A pseudogene of this gene is located on chromosome 20. Alternative splicing results in multiple transcript variants encoding different isoforms. Protein function: E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). The ATG12- ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8-like proteins from ATG3 to phosphatidylethanolamine (PE). This step is required for the membrane association of ATG8-like proteins. The formation of the ATG8-phosphatidylethanolamine conjugates is essential for autophagy and for the cytoplasm to vacuole transport (Cvt). Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with ATG3. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway. [The UniProt Consortium]
Schlagworte: Anti-ATG3, Anti-APG3, Anti-hApg3, Anti-APG3-like, EC=6.3.2.-, Anti-Protein PC3-96, Anti-Autophagy-related protein 3, Anti-Ubiquitin-like-conjugating enzyme ATG3, ATG3 Polyclonal Antibody
Hersteller: Elabscience
Hersteller-Nr: E-AB-14582

Eigenschaften

Anwendung: WB, IHC, ELISA
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Reaktivität: Human, Mouse, Rat
Immunogen: Recombinant protein of human ATG3
Format: Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: -20°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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