Anti-ARG2

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ATA-HPA000663.25 25 µl -

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156,00 €
ATA-HPA000663.100 100 µl -

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363,00 €
 
Protein function: May play a role in the regulation of extra-urea cycle arginine metabolism and... mehr
Produktinformationen "Anti-ARG2"
Protein function: May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated CD4(+) and CD8(+) T cells (PubMed:27745970). May suppress inflammation- related signaling in asthmatic airway epithelium (PubMed:27214549). May contribute to the immune evasion of H.pylori by restricting M1 macrophage activation and polyamine metabolism. In fetal dendritic cells may play a role in promoting immune suppression and T cell TNF-alpha production during gestation (PubMed:28614294). Regulates RPS6KB1 signaling, which promotes endothelial cell senescence and inflammation and implicates NOS3/eNOS dysfunction (PubMed:22928666). Can inhibit endothelial autophagy independently of its enzymatic activity implicating mTORC2 signaling (PubMed:25484082). Involved in vascular smooth muscle cell senescence and apoptosis independently of its enzymatic activity (PubMed:23832324). Since NOS is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase-2 plays a role in both male and female sexual arousal (PubMed:12859189). [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 80% and to rat: 81%
Schlagworte: Anti-ARG2, Anti-Arginase II, Anti-Type II arginase, Anti-Kidney-type arginase, Anti-Non-hepatic arginase, Anti-Arginase-2, mitochondrial
Hersteller: Atlas Antibodies
Hersteller-Nr: HPA000663

Eigenschaften

Anwendung: IHC
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Reaktivität: Human
Immunogen: Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: MSLRGSLSRL LQTRVHSILK KSVHSVAVIG APFSQGQKRK GVEHGPAAIR EAGLMKRLSS LGCHLKDFGD LSFTPVPKDD LYNNLIVNPR SVGLANQELA EVVSRAVSDG YSCVTLGGDH SLAIGTISGH ARHCPDLCVV WVDAHAD (ATA-APrEST70329)

Datenbank Information

KEGG ID : K01476 | Passende Produkte
UniProt ID : P78540 | Passende Produkte
Gene ID : GeneID 384 | Passende Produkte
Protein Atlas Nr. : ENSG00000081181

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +20°C (International: +20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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