Anti-APEX1 (DNA-(Apurinic or Apyrimidinic Site) Lyase, APEX Nuclease, APEN, Apurinic-apyrimidinic En

Anti-APEX1 (DNA-(Apurinic or Apyrimidinic Site) Lyase, APEX Nuclease, APEN, Apurinic-apyrimidinic En
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
A2298-74C5.100 100 µg - -

3 - 19 Werktage*

629,00 €
 
Human apurinic (apyrimidinic) endonuclease:redox-factor 1 (APE/Ref-1) is involved in the repair... mehr
Produktinformationen "Anti-APEX1 (DNA-(Apurinic or Apyrimidinic Site) Lyase, APEX Nuclease, APEN, Apurinic-apyrimidinic En"
Human apurinic (apyrimidinic) endonuclease:redox-factor 1 (APE/Ref-1) is involved in the repair of DNA damage as well as in the transcriptional regulation of genes. The repair function of the protein is located on its C-terminal region. Activation of transcription factors, which occurs via a redox-based mechanism, pertains to a approximately 6kD N-terminal fragment with Cys-65 being of essential importance. Ape1/ref-1 has been shown to stimulate the DNA binding activity of numerous transcription factors that are involved in cancer promotion and progression such as Fos, Jun, NFkB, PAX, HIF-1, HLF and p53. APE/Ref-1 is part of the cellular response to oxidative stress and protects cells from the genotoxic and cytotoxic effect of oxidizing agents. Thus, specific downmodulation of APE:Ref-1 activity in tumors might be considered as a novel therapeutic approach in tumor therapy. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1-2ug/ml, Optimal dilutions to be determined by the researcher. Positive Control: HeLa, Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Schlagworte: EC=3.1.-.-, EC=4.2.99.18, Anti-APEX nuclease, Anti-Redox factor-1, Anti-AP endonuclease 1, Anti-Apurinic-apyrimidinic endonuclease 1, Anti-DNA-(apurinic or apyrimidinic site) lyase, Anti-DNA-(apurinic or apyrimidinic site) lyase, mitochondrial
Hersteller: United States Biological
Hersteller-Nr: A2298-74C5

Eigenschaften

Anwendung: WB
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human
Immunogen: Synthetic peptides corresponding to aa36-52 and 216-232 of human APE (KLH).
Format: Affinity Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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