Anti-alpha Synuclein

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ARG40580.100 100 µl - -

6 - 14 Werktage*

505,00 €
 
Protein function: Neuronal protein that plays several roles in synaptic activity such as... mehr
Produktinformationen "Anti-alpha Synuclein"
Protein function: Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores (PubMed:28288128, PubMed:30404828). Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis (PubMed:30404828). Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein- alpha/DNAJC5 (PubMed:20798282). This chaperone activity is important to sustain normal SNARE-complex assembly during aging (PubMed:20798282). Plays also a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity (PubMed:26442590). [The UniProt Consortium]
Schlagworte: Anti-SNCA, Anti-NACP, Anti-Alpha-synuclein, Anti-Non-A beta component of AD amyloid, Anti-Non-A4 component of amyloid precursor
Hersteller: Arigo Biolaboratories
Hersteller-Nr: ARG40580

Eigenschaften

Anwendung: FC, ICC, IF, IHC (paraffin), IP, WB
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Reaktivität: Human
Immunogen: Synthetic peptide derived from Human alpha Synuclein
MW: 14 kD
Format: Affinity Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: °C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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