Anti-Adenosine Receptor A2A Monoclonal Antibody (Clone 7F6-G5-A2)

Adenosine receptor A2A Monoclonal Antibody (A2AR) is a multi-pass membrane protein that is normally localized to the plasma membrane. This receptor is part of the G protein-coupled receptor family that binds adenosine and serves multiple functions. Antagonists of this receptor have been targeted for the treatment of Parkinson's disease. Early reports found this receptor is found primarily in the brain striatum, but is also found in immune cells and other tissues as well. A2AR is comprised of 412 amino acids with an expected molecular weight of 45 kDa. However multiple glycosylation sites exist that may explain the retarded migration observed by western blotting (45-50 kDa). This antibody has been extensively characterized and the epitope has been mapped to the third intracellular loop of the receptor.Synonyms: A2AR, ADORA2A. Immunogen: Human full length A2AR, the antibody recognizes amino acids 213-220 (SQPLPGER) as determined by epitope mapping. Clone Designation: 7F6-G5-A2. Formulation: (Request formulation change), 500 µg affinity-purified monoclonal antibody. Storage Buffer: PBS, pH 7.2, with 50% glycerol, 0.5 mg/ml BSA, and 0.02% sodium azide. Host: Mouse. Isotype: IgG2a. Applications: WB. Cross Reactivity: (+) Human A2AR, (-) A1R, (-) A2BR. Origin: Animal/Mouse.