Anti-ADAM17 (Snake venom-like protease, TNF-alpha convertase, TNF-alpha-converting enzyme, CD_antige

Anti-ADAM17 (Snake venom-like protease, TNF-alpha convertase, TNF-alpha-converting enzyme, CD_antige
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
144125.100 100 µg - -

3 - 19 Werktage*

659,00 €
 
ADAM17(ADAM metallopeptidase domain 17), also called TACE (tumor necrosis factor-alpha-converting... mehr
Produktinformationen "Anti-ADAM17 (Snake venom-like protease, TNF-alpha convertase, TNF-alpha-converting enzyme, CD_antige"
ADAM17(ADAM metallopeptidase domain 17), also called TACE (tumor necrosis factor-alpha-converting enzyme), is a 70-kDa enzyme that belongs to the ADAM protein family of disintegrins and metalloproteases. Expression studies showed that the encoded protein cleaves precursor tumor necrosis factor-alpha to its mature form. Northern blot analysis revealed that the gene was expressed as a 5-kb mRNA in all tissues examined. ADAM17 is understood to be involved in the processing of tumor necrosis factor alpha (TNF-alpha) at the surface of the cell, and from within theintracellular membranes of the trans-Golgi network. This process, which is also known as 'shedding', involves the cleavage and release of a soluble ectodomain from membrane-bound pro-proteins (such as pro-TNF-alpha), and is of known physiological importance. ADAM17 was the first 'sheddase' to be identified, and is also understood to play a role in the release of a diverse variety of membrane-anchored cytokines, cell adhesion molecules,receptors, ligands, and enzymes. UniProt Number: P78536, Gene ID: ADAM17, Applications: Suitable for use in Western Blot. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Handling: Store at -20?C for one year. After reconstitution, store at 4?C for one month. Can also be aliquoted and stored frozen at -20?C for long term., Avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Hersteller: United States Biological
Hersteller-Nr: 144125

Eigenschaften

Anwendung: WB
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human, mouse, rat
Format: Affinity Purified

Datenbank Information

UniProt ID : P78536 | Passende Produkte

Handhabung & Sicherheit

Lagerung: vT
Versand: +4°C (International: °C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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