Produkte von LC Laboratories

LC Laboratories

LC Laboratories aus Woburn, Massachusetts, liefert seit 1980 Small Molecules für die Forschung. Zahlreiche Hersteller von Reagenzien verkaufen die hochwertigen Produkte von LC Laboratories unter ihrem eigenen Label. Wenn Sie im Bereich Signaltransduktion, Onkologie oder anderer präklinischer Forschung unterwegs sind, haben Sie sich wahrscheinlich von Anfang an, bewußt oder unbewußt, auf LC Labs-Produkte verlassen.

Mehr unter: www.lclabs.com

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Pemafibrate, Free Acid
Pemafibrate, Free Acid

Artikelnummer: LC-P-5115_100mg

Soluble in DMSO.
Schlagworte: K-877, R-K-13675
Anwendung: Antihyperlipidemic, Triglyceride synthesis inhibitor, PPAR alpha agonist
CAS 848259-27-8
MW: 490.55 D
ab 76,00 €
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SB431542, Free Base
SB431542, Free Base

Artikelnummer: LC-S-7800_100mg

Soluble in DMSO. SB-431542 selectively inhibited Smad3 phosphorylation, with an IC50 of 94 nM. It also blocked TGF-beta1-induced nuclear Smad3 localization. Laping N.J., et al. 'Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor...
Schlagworte: SB 431542, 4-(5-Benzol[1,3]dioxol-5-yl-4-pyrldin-2-yl-1H-imidazol-2-yl)-benzamide hydrate,...
Anwendung: Smad3 phosphorylation inhibitor, TGFBR1/ALK4/ALK7 kinase inhibitor
CAS 301836-41-9
MW: 384.39 D
ab 82,00 €
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Daunorubicin, Hydrochloride Salt
Daunorubicin, Hydrochloride Salt

Artikelnummer: LC-D-6660_100mg

Soluble in DMSO. Daunorubicin, also known as daunomycin, is an anthracycline antibiotic that is one of the major antitumor agents widely used in the treatment of acute myeloid leukemia, acute lymphocytic leukemia, chronic myelogenous leukemia, and Kaposi's sarcoma. Daunomycin and Actinomycin reduced mitotic activity...
Schlagworte: Cerubidine, Daunoblastin, NDC 0082-4155, Ondena, RP 13057, Rubidomycin
Anwendung: Antineoplastic, Topoisomerase II inhibitor
CAS 23541-50-6
MW: 563.98 D
ab 72,00 €
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GW7647, Free Acid
GW7647, Free Acid

Artikelnummer: LC-G-1111_100mg

Soluble in DMSO. GW7647 is a peroxisome proliferator-activated receptor-alpha (PPAR-alpha) agonist. A synergistic antinociceptive interaction between the endogenous cannabinoid receptor agonist anandamide and GW7647 was demonstrated in a model of acute chemical-induced pain. Russo R., et al. 'Synergistic...
Anwendung: Peroxisome proliferator-activated receptor-alpha (PPAR-alpha) agonist
CAS 265129-71-3
MW: 502.75 D
ab 68,00 €
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Acalabrutinib, Free Base
Acalabrutinib, Free Base

Artikelnummer: LC-A-7337_100mg

Soluble in DMSO. Acalabrutinib, also known as ACP-196, is an irreversible Bruton tyrosine kinase (BTK) inhibitor. It binds covalently to Cys481 with improved selectivity and in vivo target coverage. Acalabrutinib inhibited BTK with an IC50 of 3 nM and had improved target specificity over ibrutinib with 323-, 94-,...
Schlagworte: ACP196, ACP-196
Anwendung: Antineoplastic, Bruton's tyrosine kinase (BTK) inhibitor
CAS 1420477-60-6
MW: 465.51 D
ab 72,00 €
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Enasidenib, Free Base
Enasidenib, Free Base

Artikelnummer: LC-E-2121_100mg

Soluble in DMSO. Enasidenib, also known as AG221, is a potent and selective IDH2 mutant enzyme inhibitor. It caused a significant decrease in R(-)-2-hydroxyglutarate in marrow, plasma, and urine and showed a dose-dependent survival benefit in a primary human AML xenograft model carrying the IDH2 R140Q mutation. Wang...
Schlagworte: AG221
Anwendung: Antineoplastic, Potent, selective IDH2 mutant enzyme inhibitor
CAS 1446502-11-9
MW: 473.38 D
ab 72,00 €
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Niraparib, Free Base
Niraparib, Free Base

Artikelnummer: LC-N-5665_100mg

Soluble in DMSO. Niraparib, also known as MK-4827, is a poly(ADP-ribose)polymerase (PARP) inhibitor. Niraparib displayed excellent PARP 1 and 2 inhibition with IC50 values of 3.8 and 2.1 nM, respectively, and in a whole cell assay, it inhibited PARP activity with an IC50 of 4 nM, and inhibited proliferation of...
Schlagworte: MK-4827
Anwendung: Antineoplastic, PARP inhibitor
CAS 1038915-60-4
MW: 320.39 D
ab 75,00 €
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Niraparib, p-Toluenesulfonate Salt
Niraparib, p-Toluenesulfonate Salt

Artikelnummer: LC-N-5688_100mg

Soluble in DMSO. Niraparib enhanced radiation-induced cytotoxicity in neuroblastoma cells. In vivo treatment with niraparib and radiation prolonged survival of mice in a murine xenograft model of metastatic neuroblastoma when compared to single modalities. Mueller S., et al. 'Poly (ADP-Ribose) polymerase inhibitor...
Schlagworte: MK-4827
Anwendung: Antineoplastic, PARP inhibitor
CAS 1038915-73-9
MW: 492.59 D
ab 75,00 €
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Nilotinib, Hydrochloride Salt, Monohydrate
Nilotinib, Hydrochloride Salt, Monohydrate

Artikelnummer: LC-N-8266_10g

Soluble in DMSO. Nilotinib, a novel, selective BCR-ABL inhibitor, fits into the ATP-binding site of the BCR-ABL protein with higher affinity than imatinib. Nilotinib is not only more potent than imatinib against wild-type BCR-ABL (IC50 < 30 nM), but also significantly active against 32/33 imatinib-resistant BCR-ABL...
Schlagworte: AMN-107
Anwendung: Antineoplastic, Tyrosine kinase inhibitor
CAS 923288-90-8
MW: 584 D
ab 80,00 €
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GW590735, Free Acid
GW590735, Free Acid

Artikelnummer: LC-G-7322_100mg

Soluble in DMSO. GW590735 is a potent and selective PPARalpha agonist. It stimulated PPARalpha with an EC50 of 4 nM and had at least 500-fold selectivity on PPARalpha versus PPARdelta and PPARgamma. It raised circulating levels of high-density lipoprotein cholesterol. Sierra M.L., et al. 'Substituted...
Anwendung: Peroxisome proliferator-activated receptor-alpha (PPAR-alpha) agonist
CAS 622402-22-6
MW: 478.48 D
ab 90,00 €
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Osimertinib, Methanesulfonate Salt
Osimertinib, Methanesulfonate Salt

Artikelnummer: LC-O-7233_100mg

Soluble in DMSO. This research compound is the methanesulfonate salt form of osimertinib. Osimertinib, also known as AZD9291, is an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI). EGFR TKIs have been used to treat patients with non-small-cell lung cancer (NSCLC) harboring sensitizing...
Schlagworte: AZD9291, Mereletinib
Anwendung: Antineoplastic, EGFR tyrosine kinase inhibitor
CAS 1421373-66-1
MW: 595.72 D
ab 76,00 €
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Vandetanib, Free Base
Vandetanib, Free Base

Artikelnummer: LC-V-9402_100mg

Solubility: Soluble in DMSO at 30 mg/mL, soluble in ethanol at 10 mg/mL with warming, very poorly soluble in water, maximum solubility in plain water is estimated to be about 10-20 µM, buffers, serum, or other additives may increase or decrease the aqueous solubility. Vandetanib inhibits VEGFR-dependent tumor...
Schlagworte: ZD6474
Anwendung: VEGFR / EGFR Kinase inhibitor
CAS 443913-73-3
MW: 475,35 D
ab 82,00 €
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