Produkte von LC Laboratories

LC Laboratories

LC Laboratories aus Woburn, Massachusetts, liefert seit 1980 Small Molecules für die Forschung. Zahlreiche Hersteller von Reagenzien verkaufen die hochwertigen Produkte von LC Laboratories unter ihrem eigenen Label. Wenn Sie im Bereich Signaltransduktion, Onkologie oder anderer präklinischer Forschung unterwegs sind, haben Sie sich wahrscheinlich von Anfang an, bewußt oder unbewußt, auf LC Labs-Produkte verlassen.

Mehr unter: www.lclabs.com

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Neratinib, Free Base
Neratinib, Free Base

Artikelnummer: LC-N-6404_100mg

Solubility: Soluble in DMSO at 2 mg/mL with warming, very poorly soluble in ethanol, very poorly soluble in water, maximum solubility in plain water is estimated to be about 5-20 µM, buffers, serum, or other additives may increase or decrease the aqueous solubility. Neratinib, also known as HKI-272, is considered to...
Schlagworte: HKI-272
Anwendung: EGFR/ ERBB2 inhibitor
CAS 698387-09-6
MW: 557,04 D
ab 62,00 €
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Ibrutinib, Free Base
Ibrutinib, Free Base

Artikelnummer: LC-I-3311_100mg

Solubility: Soluble in DMSO at 200 mg/mL, soluble in ethanol at 25 mg/mL with slight warming. Ibrutinib, also known as PCI-32765, is a selective and irreversible inhibitor of the enzyme Bruton's tyrosine kinase (BTK). It inhibited BTK potently, with an IC50 of 0.72 nM in enzymology assays and with an IC50 of 10 nM...
Schlagworte: CRA-032765, PCI-32765, PCI-32765-00
Anwendung: Selective, irreversible Bruton's tyrosine kinase (BTK) inhibitor
CAS 936563-96-1
MW: 440.5 D
ab 74,00 €
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Temsirolimus
Temsirolimus

Artikelnummer: LC-T-8040_100mg

Solubility: Soluble in DMSO at 200 mg/mL, soluble in ethanol at 200 mg/mL, very poorly soluble in water, maximum solubility in plain water is estimated to be about 10-20 µM, buffers, serum, or other additives may increase or decrease the aqueous solubility. Temsirolimus, a rapamycin (sirolimus) derivative, also...
Schlagworte: CCI-779
Anwendung: Antineoplastic, MTOR inhibitor
CAS 162635-04-3
MW: 1030.29 D
ab 80,00 €
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Alectinib, Free Base
Alectinib, Free Base

Artikelnummer: LC-A-2300_100mg

Soluble in DMSO.. Alectinib, also known as CH 5424802, is a potent, selective, and orally available ALK inhibitor (IC50 = 1.9 nM) and has weak or no inhibition against 24 other tested protein kinases. It has selective antitumor activity against cancers with ALK gene alterations, including non-small cell lung cancer...
Schlagworte: CH 5424802
Anwendung: Antineoplastic, Anaplastic lymphoma kinase (ALK) inhibitor
CAS 1256580-46-7
MW: 482.62 D
ab 83,00 €
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Baricitinib, Free Base
Baricitinib, Free Base

Artikelnummer: LC-B-1600_100mg

Soluble in DMSO. Baricitinib, also known as INCB028050, is a janus kinase (JAK) inhibitor. It potently and selectively inhibited JAK1 and JAK2 kinases with IC50 values of 5.9 nM and 5.7 nM, respectively. It inhibited intracellular signaling of multiple proinflammatory cytokines including IL-6 and IL-23, with IC50...
Schlagworte: NCB028050, LY3009104
Anwendung: Antiinflammatory, Antirheumatic, Immunosuppressant, Janus kinase (JAK) inhibitor
CAS 1187594-09-7
MW: 371.42 D
ab 71,00 €
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Brigatinib, Free Base
Brigatinib, Free Base

Artikelnummer: LC-B-9800_100mg

Soluble in DMSO. Brigatinib, also known as AP26113, inhibited ALK, IGF-1R, and InsR kinases with IC50 values of 0.37 nM, 24.9 nM, and 196 nM, respectively. It blocked the viability of Karpas 299 cells (ALK+) with an IC50 of 29 nM in vitro. It demonstrated efficacy in multiple ALK+ xenografts in mice, including...
Schlagworte: AP26113
Anwendung: Antineoplastic, Anaplastic lymphoma kinase (ALK) inhibitor
CAS 1197953-54-0
MW: 584.09 D
ab 71,00 €
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Cobimetinib, Free Base
Cobimetinib, Free Base

Artikelnummer: LC-C-1100_100mg

Soluble in DMSO. Cobimetinib demonstrated a sustained tumor pharmacodynamic response due to longer residence times in tumor tissue than in plasma in mice. Following single doses, cobimetinib inhibited pERK in tumors with IC50 values of 780 nM in WM-266-4 and 520 nM in A375 xenograft mice. Following multiple doses,...
Schlagworte: GDC0973, RG7420, XL518
Anwendung: Antineoplastic, Mitogen-activated extracellular signal-regulated kinase (MEK) inhibitor
CAS 934660-93-2
MW: 531.31 D
ab 76,00 €
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Imatinib, Free Base
Imatinib, Free Base

Artikelnummer: LC-I-5577_10g

Solubility: Soluble in DMSO at 25 mg/mL with slight warming, soluble in ethanol at 5 mg/mL with slight warming, very poorly soluble in water, maximum solubility in plain water is estimated to be about 5-20 µM, buffers, serum, or other additives may increase or decrease. This is the free base form of imatinib, please...
Schlagworte: CGP-57148B, STI-571
Anwendung: Antineoplastic, Tyrosine kinase inhibitor
CAS 152459-95-5
MW: 493.6 D
ab 82,00 €
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Lenvatinib, Free Base
Lenvatinib, Free Base

Artikelnummer: LC-L-5400_100mg

Soluble in DMSO. Lenvatinib, also known as E7080, is an active inhibitor of multiple receptor tyrosine kinases, with IC50 values of 22 nM (VEGFR1), 4 nM (VEGFR2), 5.2 nM (VEGFR3), 46 nM (FGFR1), 51 nM (PDGFRa), 39 nM (PDGFRb), and 100 nM (KIT). It inhibited SCF- and VEGF-induced angiogenesis of human umbilical vein...
Schlagworte: E7080, ER20349200
Anwendung: Antineoplastic, Receptor tyrosine kinase inhibitor
CAS 417716-92-8
MW: 426.85 D
ab 72,00 €
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PLX4720, Free Base
PLX4720, Free Base

Artikelnummer: LC-P-8900_100mg

Soluble in DMSO. PLX4720 is a kinase inhibitor with marked selectivity against B-Raf(V600E), with an IC50 of 13 nM. PLX4720 induced cell cycle arrest and apoptosis exclusively in B-Raf(V600E)-positive cells in melanoma models. In B-Raf(V600E)-dependent tumor xenograft models, PLX4720 caused significant tumor growth...
Schlagworte: Raf Kinase Inhibitor V, N-[3-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide
Anwendung: B-Raf(V600E) inhibitor
CAS 918505-84-7
MW: 413.83 D
ab 77,00 €
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Trametinib, DMSO Solvate
Trametinib, DMSO Solvate

Artikelnummer: LC-T-8188_100mg

Soluble in DMSO. This research compound is the DMSO solvate form of trametinib. Trametinib is a selective MEK inhibitor. Trametinib inhibited MEK1/2 kinase activity, prevented Raf-dependent MEK phosphorylation, and produced prolonged p-ERK1/2 inhibition. It blocked the cell growth potently in most tumor lines with...
Schlagworte: GSK1120212, JTP-74057, Trametinib
Anwendung: Antineoplastic, Mitogen-activated extracellular signal-regulated kinase (MEK) inhibitor
CAS 1187431-43-1
MW: 693.53 D
ab 71,00 €
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Pemafibrate, Free Acid
Pemafibrate, Free Acid

Artikelnummer: LC-P-5115_100mg

Soluble in DMSO.
Schlagworte: K-877, R-K-13675
Anwendung: Antihyperlipidemic, Triglyceride synthesis inhibitor, PPAR alpha agonist
CAS 848259-27-8
MW: 490.55 D
ab 76,00 €
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