L3MBTL1 MBT domains (human recombinant, GST-tagged)

L3MBTL1 MBT domains (human recombinant, GST-tagged)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
Cay14775-100 100 µg -

6 - 10 Werktage*

465,00 €
 
Key Features Cayman's L3MBTL1 MBT Domains TR-FRET Assay Kit (Cay-601030) was developed using... mehr
Produktinformationen "L3MBTL1 MBT domains (human recombinant, GST-tagged)"
Key Features Cayman's L3MBTL1 MBT Domains TR-FRET Assay Kit (Cay-601030) was developed using L3MBTL1 MBT domains (human recombinant, GST-tagged) protein.Bulk sizes available upon request "The malignant brain tumor (MBT) domain is structurally related to chromatin binding domains, such as chromodomains, tudor domains, and PWWP-domains. MBT domain-containing proteins have a variable number of MBT repeats. The MBT domains recognize methylated lysines on histone tails with varying degree of specificity for the various methyl marks. L3MBTL1, a human homolog of the Drosophila lethal(3)MBT protein, is a member of the polycomb group (PcG) of proteins that functions as a transcriptional repressor. L3MBTL1 contains three MBT repeat domains which collectively bind to either histone H3 or H4. The second and third MBT domains were found to bind preferentially to mono- and dimethylated lysines of histone H3 at lysine 4 (H3K4me1) and histone H4 at lysine 20 (H4K20me2). Recognition of methyl-lysine marks by MBT domains leads to chromatin compaction and a repressed transcriptional state. Further, L3MBTL1 has a tumor suppressor function and is thought to play a role in maintaining genomic stability and DNA replication. This protein product contains the MBT repeat region of L3MBTL1."Synonyms: H-l(3)MBT, Lethal(3)Malignant Brain Tumor-like Protein 1, L(3)MBT-like. Purity: >90% estimated by SDS-PAGE. Source: Recombinant N-terminal GST-tagged protein expressed in E. coli. Amino Acids: 191-350. MW: 65.5 kDa. Formulation: (Request formulation change), 50 mM Tris, pH 8.0, with 150 mM sodium chloride and 20% glycerol.
Schlagworte: H-l(3)MBT, L(3)MBT-like, Lethal(3)Malignant Brain Tumor-like Protein 1
Hersteller: Cayman Chemical
Hersteller-Nr: 14775

Eigenschaften

Anwendung: Binding assays
Konjugat: No
Wirt: E.coli
Reinheit: >90% estimated by SDS-PAGE
Format: Solution

Handhabung & Sicherheit

Lagerung: -80°C
Versand: -80°C (International: -80°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
Hier kriegen Sie ein Zertifikat
oder , um Analysenzertifikate anzufordern.
Bewertungen lesen, schreiben und diskutieren... mehr
Kundenbewertungen für "L3MBTL1 MBT domains (human recombinant, GST-tagged)"
Bewertung schreiben
oder , um eine Produktbewertung abzugeben.
Zuletzt angesehen