Produkte von Innaxon
Innaxon ist ein Unternehmen mit Sitz in Tewkesbury, Vereinigtes Königreich, das sich auf angeborene Immunität, Toll-like Rezeptor (TLR)-Agonisten und niedermolekulare Inhibitoren konzentriert. Innaxon entwickelt und produziert definierte "Immunoceuticals" von höchster Aktivität und Reinheit für präklinische Forschungs- und Entwicklungsanwendungen für Impfstoffadjuvantien und Immuntherapie. Die einzigartigen biologischen und synthetischen TLR-Liganden von Innaxon sind gut charakterisierte und wirksame biologische Reaktionsmodifikatoren für unangemessene oder unverhältnismäßige Immunreaktionen.
Mehr Informationen unter: www.adipogen.com/innaxon
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ODN 2395 (Type C) Endotoxin-free (sterile)
Artikelnummer: IAX-200-007-C100
Optimal concentration is dependent upon cell type, species, desired activation and analysis: in vitro 0.1-1 µM (~0.7-7.0 µg/ml), in vivo 50-250 µg in rodent animal models. Negative control: Neutral-ODN (Cat. No.: IAX-200-202).
| Schlagworte: | CpG ODN: C Type (species: human and rodent) |
| Anwendung: | TLR9 activator |
| MW: | 7068 D |
ab 218,00 €
iODN (inhibitory ODN) (ttaggg)4 Endotoxin-free (sterile)
Artikelnummer: IAX-200-051-C100
Potent sequence of an inhibitory ODN for in vivo use in rodents (100-300 µg per injection), prototype class II, inhibits STAT signaling, independent of TLR signaling. Negative control: Neutral-ODN (Cat. No.: IAX-200-202).
| Schlagworte: | Inhibitory ODN (iODN): Class II |
| Anwendung: | STAT signaling inhibitor |
| MW: | 8288 D |
ab 179,00 €
Mini-iODN (inhibitory ODN) Endotoxin-free (sterile)
Artikelnummer: IAX-200-053-C100
Potent sequence of an inhibitory ODN for in vivo use in rodents (50-150 µg per injection): prototype class I, may also affect TLR7 and TLR8 signaling. egative control: Neutral-ODN (Cat. No.: IAX-200-202).
| Schlagworte: | Inhibitory ODN (iODN): Class I |
| Anwendung: | TLR9 competitor |
| MW: | 3584 D |
179,00 €
Mega-iODN (inhibitory ODN) Endotoxin-free (sterile)
Artikelnummer: IAX-200-054-C100
Particularly potent sequence of an inhibitory ODN for in vivo use in rodents (50-150µg per injection): based on class I (ODN H154) and class II (ODN A151) sequences to combine inhibitory activity on TLRs and STAT signaling. Negative control: Neutral-ODN (Cat. No.: IAX-200-202).
| Schlagworte: | Inhibitory ODN (iODN): Class I/II |
| Anwendung: | TLR9 competitor |
| MW: | 5894 D |
179,00 €
Duo-iODN (inhibitory ODN) Endotoxin-free (sterile)
Artikelnummer: IAX-200-055-C100
Potent sequence of an inhibitory ODN for in vivo use in rodents (50-150µg per injection): prototype class I that also inhibits TLR7 signaling. Negative control: Neutral-ODN (Cat. No.: IAX-200-202).
| Schlagworte: | Inhibitory ODN (iODN): Class I |
| Anwendung: | TLR9 competitor |
| MW: | 5867 D |
ab 179,00 €
ODN 2218 (Control for ODN 1585) Endotoxin-free (sterile)
Artikelnummer: IAX-200-203-C100
Negative control GpC ODN for in vivo use in rodents (50-150 µg per injection). As active compound use CpG ODN M362 (Cat. No.: IAX-200-004). For negative control without agonistic nor antagonistic activity: Neutral-ODN (Cat. No.: IAX-200-202).
| Anwendung: | Negative Control for ODN M362 (IAX-200-004) |
| MW: | 8073 D |
179,00 €
ODN M383 (Control for ODN M362) Endotoxin-free (sterile)
Artikelnummer: IAX-200-204-C100
Negative control GpC ODN for in vivo use in rodents (50-150 µg per injection). As active compound use CpG ODN 2216 (Cat. No.: IAX-200-005). For negative control without agonistic nor antagonistic activity: Neutral-ODN (Cat. No.: IAX-200-202).
| Anwendung: | Negative Control for ODN 2216 (IAX-200-005) |
| MW: | 8073 D |
179,00 €
TLR7-iODN (inhibitory ODN) Endotoxin-free (sterile)
Artikelnummer: IAX-200-056-C100
In recent years several groups have studied the sequence requirements, specificity, signaling pathways and kinetics of the TLR (Toll-like receptor) 9 suppression by inhibitory oligonucleotide motifs, which led to a class of novel inhibitory oligonucleotide (iODNs), that is independent of the previously thought...
| Schlagworte: | Inhibitory ODN (iODN): Class I/III, ODN immunoregulatory sequence 661 (IRS661) |
| Anwendung: | Immune modulator |
| MW: | 6761 D |
ab 179,00 €
CTRL2-ODN (Control for iODN and CpG-ODNs) Endotoxin-free...
Artikelnummer: IAX-200-208-C100
Unmethylated CG dinucleotides within particular sequence contexts are responsible for the immunostimulatory activity of bacterial DNA. Synthetic oligonucleotides (ODN) that contain such CpG motifs (CpG ODNs) mimic microbial DNA. The innate immune system of vertebrates has the ability to recognize CpG motifs in...
| Schlagworte: | CTRL ODN 2, Negative Control for inhibitory ODNs (iODNs) and CpG ODNs (TLR9 agonists) |
| Anwendung: | Immune modulator |
| Spezies-Reaktivität: | human, mouse, rat |
| MW: | 7324 D |
ab 179,00 €
Physiological Saline [Sodium Chloride 0.9%]...
Artikelnummer: IAX-900-003-3010
Chemical. Use for the dilution of TLRpureTM LPS and solubilisation of endotoxin-free reagents (e.g. ODNs).
| Schlagworte: | Sodium Chloride 0.9% |
| CAS | 7647-14-5 |
ab 34,00 €
ddWater Endotoxin-free (sterile)
Artikelnummer: IAX-900-002-LD15
Chemical. Endotoxin free diluent buffer used for the dilution of TLRpure LPS, MPLA and Lipid A and solubilisation of endotoxin-free reagents (e.g. ODNs).
| Schlagworte: | double-distilled Water |
| CAS | 7732-18-5 |
| MW: | 18 D |
ab 34,00 €
PBS Endotoxin-free (sterile)
Artikelnummer: IAX-900-001-L010
Chemical. Endotoxin free buffer used for the dilution of TLRpure LPS and solubilisation of endotoxin-free reagents (e.g. ODNs).
| Schlagworte: | Phosphate Buffer Saline Endotoxin-free (sterile) |
ab 34,00 €