Produkte von Indigo Biosciences
Indigo Biosciences, Inc. wurde im Jahr 2005 in State College, Pennsylvania von Dr. Jack Vanden Heuvel und Dr. Blake Peterson gegründet. Das biowissenschaftliche Unternehmen konzentriert sich auf Produkte und Dienstleistungen im Bereich in vitro-Toxikologie und Kernrezeptoren. Diese Rezeptoren stellen eine wichtige Klasse von therapeutischen Wirkstoffzielen dar. Hierbei sind quantitative Aktivitätsassays noch immer eine besondere Herausforderung für die Biotechnologie. Die beiden Gründer des Unternehmens sind international anerkannte Spezialisten auf diesem Gebiet und nutzten ihre gesammelte Expertise in der Kernrezeptorbiologie, Toxikologie, medizinischer Chemie und Molekularbiologie, um die Technologie-Plattform für diese Produkte zu entwickeln.
Mehr Informationen unter: www.indigobiosciences.com
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Nrf2 (Human) Reporter Assay System
Artikelnummer: IB-IB10002
Protein function: Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating...
| Schlagworte: | NRF2, HEBP1, NFE2L2, NFE2-related factor 2, NF-E2-related factor 2, Nuclear factor erythroid 2-related factor 2, Nuclear... |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | human |
3.802,00 €
LXRalpha (human) Reporter Assay Kit
Artikelnummer: IB-IB00311
This nuclear receptor assay system utilizes proprietary non-human mammalian cells engineered to provide constitutive, high-level expression of human liver X receptor alpha (NR1H3), a ligand-dependent transcription factor commonly referred to as LXRalpha. INDIGO's reporter cells include the luciferase reporter gene...
| Schlagworte: | LXRA, NR1H3, Liver X receptor alpha, Oxysterols receptor LXR-alpha, Nuclear receptor subfamily 1 group H member 3 |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | human |
ab 1.448,00 €
CAR3 (human) Reporter Assay Kit
Artikelnummer: IB-IB00901
This nuclear receptor assay system utilizes proprietary non-human mammalian cells engineered to provide constitutive, high-level expression of human constitutive androstane receptor, isoform 3 (NR1I3), a ligand-dependent transcription factor commonly referred to as CAR3. These reporter cells utilize a modified...
| Schlagworte: | CAR, NR1I3, Constitutive active response, Orphan nuclear receptor MB67, Constitutive androstane receptor, Constitutive... |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | human |
ab 1.448,00 €
PR (human) Reporter Assay Kit
Artikelnummer: IB-IB05001
This nuclear receptor assay system utilizes proprietary human cells engineered to provide constitutive, high-level expression of the full-length human progesterone receptor (NR3C3), a ligand-dependent transcription factor commonly referred to as PR. INDIGO's reporter cells include the luciferase reporter gene...
| Schlagworte: | PR, PGR, NR3C3, Progesterone receptor, Nuclear receptor subfamily 3 group C member 3 |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | human |
ab 1.448,00 €
ERRalpha (human) Reporter Assay Kit
Artikelnummer: IB-IB08001
This nuclear receptor assay system utilizes proprietary human mammalian cells engineered to provide high-level expression of a hybrid form of the human estrogen-related receptor alpha (NR3B1). The N-terminal DNA binding domains (DBD) of the native ERRalpha has been substituted with that of the yeast GAL4-DBD. The...
| Schlagworte: | ERR1, ESRRA, ERR-alpha, Estrogen receptor-like 1, Steroid hormone receptor ERR1, Estrogen-related receptor alpha, Nuclear... |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | human |
ab 1.448,00 €
ERRgamma (human) Reporter Assay Kit
Artikelnummer: IB-IB08021
This nuclear receptor assay system utilizes proprietary non-human mammalian cells engineered to provide high-level expression of a hybrid form of the Human Estrogen-Related Receptor gamma (NR3B3). The N-terminal DNA binding domains (DBD) of the native ERRgamma has been substituted with that of the yeast GAL4-DBD....
| Schlagworte: | Estrogen-Related Receptor gamma (human) Reporter Assay Kit, NR3B3, ERR3, ESRRG, ERR gamma-2, Estrogen-related receptor... |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | human |
ab 1.448,00 €
PPARdelta (mouse) Reporter Assay Kit
Artikelnummer: IB-M00121
This nuclear receptor assay system utilizes proprietary non-human cells engineered to provide constitutive, high-level expression of the mouse peroxisome proliferator-activated receptor delta (NR1C2), a ligand-dependent transcription factor commonly referred to as PPARD or PPARdelta. INDIGO's reporter cells include...
| Schlagworte: | NUC1, Nr1c2, Ppard, PPAR-beta, PPAR-delta, Nuclear hormone receptor 1, Nuclear receptor subfamily 1 group C member 2,... |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | mouse |
ab 1.448,00 €
CAR (Mouse) Reporter Assay System
Artikelnummer: IB-M00901
Protein function: Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element. [The...
| Schlagworte: | Car, CAR, Nr1i3, Orphan nuclear receptor MB67, Constitutive androstane receptor, Nuclear receptor subfamily 1 group I... |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | mouse |
ab 1.448,00 €
PXR (Cynomolgus Monkey) Reporter Assay System
Artikelnummer: IB-C07001
| Schlagworte: | Nr1i2, Nuclear receptor subfamily 1 group I member 2 |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | Cynomolgus monkey |
ab 1.448,00 €
PXR (Dog) Reporter Assay System
Artikelnummer: IB-D07001
| Schlagworte: | Nr1i2, Nuclear receptor subfamily 1 group I member 2 |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | dog |
ab 1.448,00 €
LXRbeta (human) Reporter Assay Kit
Artikelnummer: IB-IB00301
This nuclear receptor assay system utilizes proprietary non-human mammalian cells engineered to provide constitutive, high-level expression of human liver X receptor beta (NR1H2), a ligand-dependent transcription factor commonly referred to as LXRbeta. INDIGO's reporter cells include the luciferase reporter gene...
| Schlagworte: | LXRB, NR1H2, Nuclear receptor NER, Liver X receptor beta, Oxysterols receptor LXR-beta, Ubiquitously-expressed nuclear... |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | human |
ab 1.448,00 €
VDR (human) Reporter Assay Kit
Artikelnummer: IB-IB00701
This nuclear receptor assay system utilizes proprietary human cells engineered to provide constitutive, high-level expression of the human vitamin D receptor (NR1I1), a ligand-dependent transcription factor commonly referred to as VDR. INDIGO's reporter cells include the luciferase reporter gene functionally linked...
| Schlagworte: | VDR, NR1I1, Vitamin D3 receptor, 1,25-dihydroxyvitamin D3 receptor, Nuclear receptor subfamily 1 group I member 1 |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | human |
ab 1.448,00 €