Produkte von Indigo Biosciences

Indigo

Indigo Biosciences, Inc. wurde im Jahr 2005 in State College, Pennsylvania von Dr. Jack Vanden Heuvel und Dr. Blake Peterson gegründet. Das biowissenschaftliche Unternehmen konzentriert sich auf Produkte und Dienstleistungen im Bereich in vitro-Toxikologie und Kernrezeptoren. Diese Rezeptoren stellen eine wichtige Klasse von therapeutischen Wirkstoffzielen dar. Hierbei sind quantitative Aktivitätsassays noch immer eine besondere Herausforderung für die Biotechnologie. Die beiden Gründer des Unternehmens sind international anerkannte Spezialisten auf diesem Gebiet und nutzten ihre gesammelte Expertise in der Kernrezeptorbiologie, Toxikologie, medizinischer Chemie und Molekularbiologie, um die Technologie-Plattform für diese Produkte zu entwickeln.

Mehr Informationen unter: www.indigobiosciences.com

Zu den Katalogen von Indigo Biosciences

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CAR3 (human) Reporter Assay Kit
CAR3 (human) Reporter Assay Kit

Artikelnummer: IB-IB00902

This nuclear receptor assay system utilizes proprietary non-human mammalian cells engineered to provide constitutive, high-level expression of human constitutive androstane receptor, isoform 3 (NR1I3), a ligand-dependent transcription factor commonly referred to as CAR3. These reporter cells utilize a modified...
Schlagworte: CAR, NR1I3, Constitutive active response, Orphan nuclear receptor MB67, Constitutive androstane receptor, Constitutive...
Anwendung: Functional activity screening
Spezies-Reaktivität: human
3.802,00 €
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TRalpha (human) Reporter Assay Kit
TRalpha (human) Reporter Assay Kit

Artikelnummer: IB-IB01002

This nuclear receptor assay system utilizes proprietary human cells engineered to provide constitutive, high-level expression of the human thyroid hormone receptor alpha (NR1A1), a ligand-dependent transcription factor commonly referred to as TRalpha. INDIGO's reporter cells include the luciferase reporter gene...
Schlagworte: THRA, EAR7, EAR-7, c-erbA-1, c-erbA-alpha, V-erbA-related protein 7, Thyroid hormone receptor alpha, Nuclear receptor...
Anwendung: Functional activity screening
Spezies-Reaktivität: human
3.802,00 €
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TRbeta (human) Reporter Assay Kit
TRbeta (human) Reporter Assay Kit

Artikelnummer: IB-IB01102

This nuclear receptor assay system utilizes proprietary human cells engineered to provide constitutive, high-level expression of the human thyroid hormone receptor beta (NR1A2), a ligand-dependent transcription factor commonly referred to as TRbeta. INDIGO's reporter cells include the luciferase reporter gene...
Schlagworte: THRB, ERBA2, c-erbA-2, c-erbA-beta, Thyroid hormone receptor beta, Nuclear receptor subfamily 1 group A member 2
Anwendung: Functional activity screening
Spezies-Reaktivität: human
3.802,00 €
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TR (human) Reporter Assays Panel
TR (human) Reporter Assays Panel

Artikelnummer: IB-IB01201-48P

INDIGO's panel of TR reporter assays utilizes non-human mammalian cells engineered to express human thyroid hormone receptors alpha (NR1A3) and beta (NR1A2), ligand-dependent transcription factors commonly referred to as TRalpha and TRbeta. INDIGO's TR reporter cells include the luciferase reporter gene functionally...
Schlagworte: thyroid hormone receptor alpha (NR1A1), thyroid hormone receptor beta (NR1A2), Tralpha, TRbeta
Anwendung: Functional activity screening
Spezies-Reaktivität: human
1.894,00 €
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RARgamma (human) Reporter Assay Kit
RARgamma (human) Reporter Assay Kit

Artikelnummer: IB-IB02002

This nuclear receptor assay system utilizes proprietary non-human cells engineered to provide constitutive, high-level expression of the human retinoic acid receptor gamma (NR1B3), a ligand-dependent transcription factor commonly referred to as RARG or RARgamma. INDIGO's reporter cells include the luciferase...
Schlagworte: RARG, NR1B3, RAR-gamma, Retinoic acid receptor gamma, Nuclear receptor subfamily 1 group B member 3
Anwendung: Functional activity screening
Spezies-Reaktivität: human
3.802,00 €
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RARbeta (human) Reporter Assay Kit
RARbeta (human) Reporter Assay Kit

Artikelnummer: IB-IB02102

This nuclear receptor assay system utilizes proprietary non-human cells engineered to provide constitutive, high-level expression of the human retinoic acid receptor, beta (NR1B2), a ligand-dependent transcription factor commonly referred to as RARB or RARbeta. INDIGO's reporter cells include the luciferase reporter...
Schlagworte: HAP, RARB, RAR-beta, RAR-epsilon, HBV-activated protein, Retinoic acid receptor beta, Nuclear receptor subfamily 1 group B...
Anwendung: Functional activity screening
Spezies-Reaktivität: human
3.802,00 €
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RARalpha (human) Reporter Assay Kit
RARalpha (human) Reporter Assay Kit

Artikelnummer: IB-IB02202

This nuclear receptor assay system utilizes proprietary non-human cells engineered to provide constitutive, high-level expression of the human retinoic acid receptor, alpha (NR1B1), a ligand-dependent transcription factor commonly referred to as RARA or RARalpha. INDIGO's reporter cells include the luciferase...
Schlagworte: RARA, NR1B1, RAR-alpha, Retinoic acid receptor alpha, Nuclear receptor subfamily 1 group B member 1
Anwendung: Functional activity screening
Spezies-Reaktivität: human
3.802,00 €
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RAR (human) Reporter Assays Panel
RAR (human) Reporter Assays Panel

Artikelnummer: IB-IB02301-32P

INDIGO's panel of RAR reporter assays utilizes non-human mammalian cells engineered to individually express human retinoic acid receptors, RARalpha (NR1B1), RARbeta (NR1B2), or RARgamma (NR1B3). INDIGO's RAR reporter cells include the luciferase reporter gene functionally linked to a responsive promoter. Thus,...
Schlagworte: RARalpha, NR1B1, RARbeta, NR1B2, RARgamma, NR1B3, retinoic acid receptor alpha, retinoic acid receptor beta, retinoic acid...
Anwendung: Functional activity screening
Spezies-Reaktivität: human
1.894,00 €
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RORgamma (human) Reporter Assay Kit
RORgamma (human) Reporter Assay Kit

Artikelnummer: IB-IB04002

This human RAR-related orphan receptor gamma (RORgamma) mRNA is expressed from the RORC gene in two forms via alternate usage of tissue-specific promoters. Variant 1 mRNA is expressed in numerous tissues, and encodes receptor isoform 1, referred to as RORgamma. Variant 2 mRNA comprises an alternate exon 1 that...
Schlagworte: RORC, NR1F3, Nuclear receptor ROR-gamma, Nuclear receptor RZR-gamma, RAR-related orphan receptor C, Retinoid-related...
Anwendung: Functional activity screening
Spezies-Reaktivität: human
3.802,00 €
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PXR (human) Reporter Assay Kit
PXR (human) Reporter Assay Kit

Artikelnummer: IB-IB07002

Protein function: Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the...
Schlagworte: SXR, PXR, NR1I2, Pregnane X receptor, Orphan nuclear receptor PXR, Orphan nuclear receptor PAR1, Steroid and xenobiotic...
Anwendung: Functional activity screening
Spezies-Reaktivität: human
3.802,00 €
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ERRalpha (human) Reporter Assay Kit
ERRalpha (human) Reporter Assay Kit

Artikelnummer: IB-IB08002

This nuclear receptor assay system utilizes proprietary human mammalian cells engineered to provide high-level expression of a hybrid form of the human estrogen-related receptor alpha (NR3B1). The N-terminal DNA binding domains (DBD) of the native ERRalpha has been substituted with that of the yeast GAL4-DBD. The...
Schlagworte: ERR1, ESRRA, ERR-alpha, Estrogen receptor-like 1, Steroid hormone receptor ERR1, Estrogen-related receptor alpha, Nuclear...
Anwendung: Functional activity screening
Spezies-Reaktivität: human
3.802,00 €
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ERRgamma (human) Reporter Assay Kit
ERRgamma (human) Reporter Assay Kit

Artikelnummer: IB-IB08022

This nuclear receptor assay system utilizes proprietary non-human mammalian cells engineered to provide high-level expression of a hybrid form of the Human Estrogen-Related Receptor gamma (NR3B3). The N-terminal DNA binding domains (DBD) of the native ERRgamma has been substituted with that of the yeast GAL4-DBD....
Schlagworte: Estrogen-Related Receptor gamma (human) Reporter Assay Kit, NR3B3, ERR3, ESRRG, ERR gamma-2, Estrogen-related receptor...
Anwendung: Functional activity screening
Spezies-Reaktivität: human
3.802,00 €
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