CD274 [B7-H1/PD-L1] (human):Fc (human) (rec.)

CD274 [B7-H1/PD-L1] (human):Fc (human) (rec.)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
CHI-HF-210PDL1-C100 100 µg - -

3 - 9 business days*

429.00€
 
The extracellular domain of human CD274 [B7-H1] (aa 19-238) is fused to the N-terminus of the Fc... more
Product information "CD274 [B7-H1/PD-L1] (human):Fc (human) (rec.)"
The extracellular domain of human CD274 [B7-H1] (aa 19-238) is fused to the N-terminus of the Fc region of human IgG1. Lyophilized from 0.2µm-filtered solution in PBS. Programmed death ligand 1 (PD-L1, B7-H1 or CD274) is a member of the growing B7 family of immune proteins that provide signals for both stimulating and inhibiting T cell activation. CD274 has been identified as one of two ligands for programmed death 1 (PD-1), a member of the CD28 family of immunoreceptors. CD274 is widely expressed in several organs such as heart, skeletal muscle, placenta and lung, and in lower amounts in thymus, spleen, kidney and liver. CD274 expression is upregulated in a small fraction of activated T and B cells and a much larger fraction of activated monocytes. CD274 expression is also induced in dendritic cells and keratinocytes after IFN-gamma stimulation. CD274 expression is also upregulated in a variety of tumor cell lines. Interaction of CD274 with PD-1 results in inhibition of TCR mediated proliferation and cytokine production, suggesting an inhibitory role in regulating immune responses. The CD274 - PD-1 pathway is involved in the negative regulation of some immune responses and may play an important role in the regulation of peripheral tolerance.
Keywords: B7H1, B7-H1, CD274, PD-L1, B7 homolog 1, PDCD1 ligand 1, Programmed death ligand 1, Programmed cell death 1 ligand 1
Supplier: Chimerigen Laboratories
Supplier-Nr: HF-210PDL1

Properties

Application: Bioassays
Conjugate: No
Host: Hamster cells
Species reactivity: human
Purity: >98%
Format: Lyophilized

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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