Products from Cayman

Cayman

Cayman Chemical Company, headquartered in Ann Arbor, Michigan, is helping make research possible by supplying scientists with biochemical tools in research disciplines such as cancer, nitric oxide, neuroscience, apoptosis, oxidative injury, endocrinology, and much more. Cayman specializes in assay kits for the measurement of eicosanoids, free radical biomarkers, cyclic nucleotides, cytokines, hormones, and nitric oxide. In addition, Cayman offers a broad range of quality biochemicals including eicosanoids, nitric oxide reagents, and a variety of related lipids, fatty acids, enzymes, and antibodies.

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Prostaglandin E2-d9
Prostaglandin E2-d9

Item number: Cay10581-250

PGE2-d9 contains nine deuterium atoms at the 17, 17', 18, 18', 19, 19', 20, 20, and 20' positions. It is intended for use as an internal standard for the quantification of PGE2 by GC- or LC-mass spectrometry (MS). PGE2 is one of the primary cyclooxygenase products of arachidonic acid and one of the most widely investigated prostaglandins. Its activity influences...
Application: Standard
CAS 1356347-42-6
MW: 361.5 D
Purity: >99% deuterated forms (d1-d9)
Format: Solution
From 64.00€
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Exendin-4 (acetate)
Exendin-4 (acetate)

Item number: Cay11096-1

Exendin-4 is a potent peptide agonist of the glucagon-like peptide 1 (GLP-1) receptor (Ki = 136 pM). By activating the GLP-1 receptor, it stimulates glucose-induced insulin secretion in isolated rat islets and proinsulin expression in mouse insulinoma betaTC-1 cells, supporting efficacy in type 2 diabetes. Exendin-4 was first isolated from the venom of H. horridum and...
Application: GLP-1R agonist
CAS 914454-01-6
MW: 4246.6 D
Purity: >95%
Format: Crystalline Solid
From 107.00€
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Prostaglandin B1
Prostaglandin B1

Item number: Cay11110-1

Prostaglandin B1 (PGB1) is a non-enzymatic dehydration product of PGE1 resulting from treatment with strong base. Oligomers of PGB1 are known to exhibit antioxidant and ionophoric activity.
Application: Bioactive lipid assays
CAS 13345-51-2
MW: 336.5 D
Purity: >98%
Format: Crystalline Solid
From 24.00€
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Cytochalasin B
Cytochalasin B

Item number: Cay11328-5

Cytochalasin B is a cell-permeable mycotoxin which binds to the barbed end of actin, reversibly inhibiting the elongation and shortening of actin filaments. By disrupting actin polymerization, cytochalasin B blocks diverse cellular functions, including cell division, migration, phagocytosis, exocytosis, chemotaxis, and glucose transport. Cytochalasin B is broadly used in...
Application: Mycotoxin
CAS 14930-96-2
MW: 479.6 D
Purity: >98%
Format: Crystalline Solid
From 44.00€
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BAPTA
BAPTA

Item number: Cay11706-100

BAPTA is a membrane-impermeable calcium chelator that binds extracellular calcium ions. The presence of four carboxylic acid functional groups allows for the binding of two calcium ions. BAPTA and its derivatives are widely used for the measurement and manipulation of intracellular free calcium concentration.
Application: Calcium chelator
CAS 85233-19-8
MW: 476.4 D
Purity: >95%
Format: Crystalline Solid
From 32.00€
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Oleoyl Serinol
Oleoyl Serinol

Item number: Cay13637-100

Oleoyl serinol is an analog of ceramide and an agonist of the cannabinoid receptor GPR119 that has an EC50 value of 12 µM for stimulating secretion of GLP-1 in mouse endocrine GLUTag cells. It has been found in E. coli that express human microbiota N-acyl synthase (hmNAS) genes. It induces cell death of F-11 murine neuroblastoma and apoptosis in U-87 human astrocytoma cells...
Application: GPR119 agonist
CAS 72809-08-6
MW: 355.6 D
Purity: >98%
Format: Crystalline Solid
From 42.00€
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Guanosine 5'-triphosphate (sodium salt hydrate)
Guanosine 5'-triphosphate (sodium salt hydrate)

Item number: Cay16060-25

Guanosine 5'-triphosphate (GTP) acts as a substrate for the synthesis of RNA during the transcription process and the synthesis of DNA during DNA replication. It is generated by the citric acid cycle and provides a source of energy for protein synthesis and gluconeogenesis, activating substrates in metabolic reactions. GTP is essential for G protein-related signal...
Application: Substrate, Protein synthesis / gluconeogenesis energy source, G-protein ligand
CAS 24905-71-3
MW: 621.2 D
Purity: >90%
Format: Crystalline Solid
From 32.00€
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2-Hydroxypropyl-beta-cyclodextrin
2-Hydroxypropyl-beta-cyclodextrin

Item number: Cay16169-5

2-Hydroxypropyl-beta-cyclodextrin (HP-beta-CD) is a cyclic oligosaccharide containing seven D-(+)-glucopyranose units that is widely used to improve the aqueous solubility of various compounds, especially those containing a phenyl group. The circular arrangement of its glucose units produces a torus-shaped ring configuration in which the CH2 groups and ether linkages of the...
Application: Solubility enhancer
CAS 128446-35-5
MW: 1541.6 D
Purity: >95%
Format: Crystalline Solid
From 32.00€
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S-(5'-Adenosyl)-L-methionine (tosylate)
S-(5'-Adenosyl)-L-methionine (tosylate)

Item number: Cay16376-50

S-(5'-Adenosyl)-L-methionine (SAM) is a ubiquitous methyl donor involved in a wide variety of biological reactions, including those mediated by DNA and protein methyltransferases. SAM (tosylate) (SAMe) is a stable salt of SAM that is included in nutritional supplements for oral use. SAMe reportedly ameliorates depression, pain associated with osteoarthritis and fibromyalgia,...
Application: Methyl donor, Cosubstrate
CAS 52248-03-0
MW: 570.6 D
Purity: >95%
Format: Crystalline Solid
From 82.00€
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U-73343
U-73343

Item number: Cay17339-5

U-73122 (Cay-70740) is an inhibitor of PLC-dependent processes, however, the mechanism of action remains unclear. The IC50 values for inhibition of platelet aggregation induced by collagen or thrombin are 0.6 and 5 µM, respectively. It also exhibits inhibitory activity against HIV-1 integrase with an IC50 value of 7 µM. U-73343 is a close structural analog of U-73122 that...
Application: PLC inhibition negative control
CAS 142878-12-4
MW: 466.7 D
Purity: >95%
Format: Crystalline Solid
From 32.00€
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Bufuralol (hydrochloride)
Bufuralol (hydrochloride)

Item number: Cay17794-10

Bufuralol is a non-specific beta-adrenergic blocker with affinity for both beta1 and beta2-adrenergic receptors. It acts as a potent beta-adrenoceptor antagonist with partial agonist activity. It is primarily metabolized by cytochrome P450 (CYP) isoform CYP2D6, with CYP1A2 and CYP2C19 also contributing to 1'-hydroxylation.
Application: Beta-adrenoceptor antagonist
CAS 60398-91-6
MW: 297.8 D
Purity: >95%
Format: Crystalline Solid
From 82.00€
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ORY-1001
ORY-1001

Item number: Cay19136-1

Lysine-specific demethylase 1 (LSD1) demethylates H3K4 and H3K9, resulting in transcriptional repression. It also controls the tumor suppressor activity of p53 by demethylating a specific p53 lysine residue (LYS370). ORY-1001 is an orally available, selective inhibitor of LSD1 (IC50 < 20 nM). It targets acute myeloid leukemia (AML) stem cells and significantly reduces tumor...
Application: LSD1 inhibitor
CAS 1431326-61-2
MW: 303.3 D
Purity: >98%
Format: Crystalline Solid
From 32.00€
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