Products from Cayman

Cayman

Cayman Chemical Company, headquartered in Ann Arbor, Michigan, is helping make research possible by supplying scientists with biochemical tools in research disciplines such as cancer, nitric oxide, neuroscience, apoptosis, oxidative injury, endocrinology, and much more. Cayman specializes in assay kits for the measurement of eicosanoids, free radical biomarkers, cyclic nucleotides, cytokines, hormones, and nitric oxide. In addition, Cayman offers a broad range of quality biochemicals including eicosanoids, nitric oxide reagents, and a variety of related lipids, fatty acids, enzymes, and antibodies.

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Superoxide Dismutase Assay Kit
Superoxide Dismutase Assay Kit

Item number: Cay706002-96

Significant amounts of superoxide dismutase (SOD) in cellular and extracellular environments are crucial for the prevention of diseases linked to oxidative stress. Mutations in SOD account for approximately 20% of familial amyotrophic lateral sclerosis (ALS) cases. SOD also appears to be important in the prevention of other neurodegenerative disorders such as Alzheimer's,...
Application: SOD detection
Format: Homog.
From 282.00€
Review
O-1918
O-1918

Item number: Cay10004914-1

Abnormal cannabidiol is a synthetic regioisomer of cannabidiol that fails to elicit either central cannabinoid (CB1) or peripheral cannabinoid (CB2) responsiveness and is without psychotropic activity. It induces endothelium-dependent vasodilation via a CB1/CB2/nitric oxide-independent mechanism. O-1918 is a cannabidiol analog that acts as a selective antagonist of abnormal...
Application: Cannabidiol analog
CAS 536697-79-7
MW: 286.4 D
Purity: >95%
Format: Solution
From 29.00€
Review
Genistein
Genistein

Item number: Cay10005167-500

Genistein is an isoflavonoid phytoestrogenic compound found in soybeans, pea pods, and other legumes. The estimated human normal dietary intake of genistein, primarily as glycosides, is 0 to 0.5 mg/kg. Genistein is present in much greater amounts in nutritional supplements. Genistein is carcinogenic in female neonatal mice, inducing endocrine-dependent uterine tumors in a...
Application: Tyrosine kinase inhibitor
CAS 446-72-0
MW: 270.2 D
Purity: >98%
Format: Crystalline Solid
From 30.00€
Review
TOFA
TOFA

Item number: Cay10005263-5

Inhibition of fatty acid synthase (FAS) by the irreversible inhibitor cerulenin leads to cytotoxicity and apoptosis in human cancer cell lines. TOFA is an inhibitor of fatty acid synthesis blocking the synthesis of malonyl-CoA by acetyl-CoA carboxylase (ACC). Both cerulenin (at about 10 µg/ml) and TOFA (at about 1 µg/ml) are effective at blocking the incorporation of...
Application: Bioactive lipid assays
CAS 54857-86-2
MW: 324.5 D
Purity: >98%
Format: Crystalline Solid
From 37.00€
Review
11-cis Vaccenyl Acetate
11-cis Vaccenyl Acetate

Item number: Cay10010101-5

The mating and social behaviors of insects are largely orchestrated by a suite of volatile hydrocarbon pheromones. 11-cis Vaccenyl acetate is the male-specific mating pheromone of the fruit fly D. melanogaster. It acts selectively through the Or67d odorant receptor to control mating behavior in both male and female fruit flies.
Application: Mating pheromone
CAS 6186-98-7
MW: 310.5 D
Purity: >98%
Format: Solution
From 23.00€
Review
Prostaglandin E2-d9
Prostaglandin E2-d9

Item number: Cay10581-250

PGE2-d9 contains nine deuterium atoms at the 17, 17', 18, 18', 19, 19', 20, 20, and 20' positions. It is intended for use as an internal standard for the quantification of PGE2 by GC- or LC-mass spectrometry (MS). PGE2 is one of the primary cyclooxygenase products of arachidonic acid and one of the most widely investigated prostaglandins. Its activity influences...
Application: Standard
CAS 1356347-42-6
MW: 361.5 D
Purity: >99% deuterated forms (d1-d9)
Format: Solution
From 64.00€
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Camptothecin
Camptothecin

Item number: Cay11694-500

DNA topoisomerases relax DNA torsional strain created during replication, transcription, recombination, repair, and chromosome condensation. The relaxation of DNA supercoiling by topoisomerase I at single-strand breaks enables anticancer agents to reversibly trap the complex by intercalating between DNA base pairs at the cleavage site, thus inhibiting religa Camptothecin is...
Application: Topoisomerase inhibitor
CAS 7689-034
MW: 348.4 D
Purity: >98%
Format: Crystalline Solid
From 25.00€
Review
BAPTA
BAPTA

Item number: Cay11706-100

BAPTA is a membrane-impermeable calcium chelator that binds extracellular calcium ions. The presence of four carboxylic acid functional groups allows for the binding of two calcium ions. BAPTA and its derivatives are widely used for the measurement and manipulation of intracellular free calcium concentration.
Application: Calcium chelator
CAS 85233-19-8
MW: 476.4 D
Purity: >95%
Format: Crystalline Solid
From 32.00€
Review
GSK-J5 (hydrochloride)
GSK-J5 (hydrochloride)

Item number: Cay12074-1

The histone H3 lysine 27 (H3K27) demethylase JMJD3 plays important roles in the transcriptional regulation of cell differentiation, development, the inflammatory response, and cancer. GSK-J4 (Cay-12073) is a cell-permeable prodrug which is modified by intracellular esterases to give GSK-J1 (Cay-12054), an inhibitor of JMJD3. GSK-J5 is a pyridine regio-isomer of GSK-J4. Like...
Application: GSK-J4 isomer, Histone demethylase inhibitor
CAS 1797983-32-4
MW: 454 D
Purity: >95%
Format: Crystalline Solid
From 35.00€
Review
3-Methyladenine
3-Methyladenine

Item number: Cay13242-100

Autophagy is a multi-step process that involves the degradation and digestion of intracellular components by the lysosome. This process allows cells to efficiently mobilize and recycle cellular constituents, and also prevents the accumulation of damaged organelles, misfolded proteins, and invading microorganisms. mTOR, whose activation is controlled by phosphoinositide...
Application: PI3K inhibitor
CAS 5142-23-4
MW: 149.2 D
Purity: >95%
Format: Crystalline Solid
From 32.00€
Review
Tamoxifen
Tamoxifen

Item number: Cay13258-500

There are two homologous nuclear receptors for the hormone 17beta-estradiol (estrogen), commonly called ERalpha and ERbeta. Receptor activation leads to the formation of homo- and hetero-dimers, which in turn interact with accessory proteins to regulate gene transcription. Tamoxifen is a selective estrogen receptor modulator, evoking tissue-dependent effects. It is an...
Application: Estrogen receptor modulator
CAS 10540-29-1
MW: 371.5 D
Purity: >95%
Format: Crystalline Solid
From 57.00€
Review
Oleoyl Serinol
Oleoyl Serinol

Item number: Cay13637-100

Oleoyl serinol is an analog of ceramide and an agonist of the cannabinoid receptor GPR119 that has an EC50 value of 12 µM for stimulating secretion of GLP-1 in mouse endocrine GLUTag cells. It has been found in E. coli that express human microbiota N-acyl synthase (hmNAS) genes. It induces cell death of F-11 murine neuroblastoma and apoptosis in U-87 human astrocytoma cells...
Application: GPR119 agonist
CAS 72809-08-6
MW: 355.6 D
Purity: >98%
Format: Crystalline Solid
From 42.00€
Review
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