Anti-Metabotropic Glutamate Receptor 1, CT (GRM1, GPRC1A, MGLUR1, Metabotropic glutamate receptor 1)

Anti-Metabotropic Glutamate Receptor 1, CT (GRM1, GPRC1A, MGLUR1, Metabotropic glutamate receptor 1)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
038373.200 200 µl - -

3 - 19 business days*

728.00€
 
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates... more
Product information "Anti-Metabotropic Glutamate Receptor 1, CT (GRM1, GPRC1A, MGLUR1, Metabotropic glutamate receptor 1)"
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 (also known as GPRC1A) and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. The activity of GRM1 is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. This protein may participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum, Applications: Suitable for use in Western Blot, Immunohistochemistry, ELISA, Recommended Dilution: ELISA: 1:1,000, Western Blot: 1:100-500, Immunohistochemistry: 1:10-50, Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: Anti-GRM1, Anti-GPRC1A, Anti-mGluR1, Anti-Metabotropic glutamate receptor 1
Supplier: United States Biological
Supplier-Nr: 038373

Properties

Application: ELISA, IHC, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: GPRC1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1104~1133 amino acids from the C-terminal region of human GPRC1A.
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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