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Product information "AAF-CMK (trifluoroacetate salt)"
Tripeptidyl peptidase II (TPPII) is a serine peptidase of the subtilisin-type which removes tripeptides from the free NH2 terminus of oligopeptides. AAF-CMK is an irreversible inhibitor of TPPII commonly used at 10-100 µM. It does not significantly interfere with the chymotrypsin-like activity of the proteasome. AAF-CMK also inhibits bleomycin hydrolase and puromycin-sensitive aminopeptidase when used at 50 µM.Formal Name: L-alanyl-N-[(1S)-3-chloro-2-oxo-1-(phenylmethyl)propyl]-L-alaninamide, mono(trifluoroacetate). CAS Number: 184901-82-4. Synonyms: N-Ala-Ala-Phe-CMK, Tripeptidyl Peptidase Inhibitor II. Molecular Formula: C16H22ClN3O3 . CF3COOH. Formula Weight: 453.8. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: Water: 10 mg/ml. SMILES: N[C@@H](C)C(N[C@@H](C)C(N[C@@H](CC1=CC=CC=C1)C(CCl)=O)=O)=O.FC(F)(C(O)=O)F. InChi Code: InChI=1S/C16H22ClN3O3.C2HF3O2/c1-10(18)15(22)19-11(2)16(23)20-13(14(21)9-17)8-12-6-4-3-5-7-12,3-2(4,5)1(6)7/h3-7,10-11,13H,8-9,18H2,1-2H3,(H,19,22)(H,20,23),(H,6,7)/t10-,11-,13-,/m0./s1. InChi Key: ZFZXFWAYCYJFIZ-SQRKDXEHSA-N.
Keywords:
N-Ala-Ala-Phe-CMK, Tripeptidyl Peptidase Inhibitor II, L-alanyl-N-[(1S)-3-chloro-2-oxo-1-(phenylmethyl)propyl]-L-alaninamide, mono(trifluoroacetate)
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