BIOMOL Online August 2007
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New HDAC Enzymes
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5 new recombinant HDAC enzymes, active and suitable for inhibitor screening and activity assays |
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HDAC1 (human, recombinant) (Cat. #
SE-456)
Overexpressed in multiple tumor types and shown to deacetylate p53
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HDAC2 (human, recombinant) (Cat. #
SE-500)
Required for the cardiac hypertrophic response suggesting inhibition of HDAC2 as a possible therapeutic approach for heart disease |
HDAC3 (human, recombinant) (Cat. #
SE-507)
Inhibition of HDAC3 may be the determining factor in the anti-proliferative effects of HDAC inhibitors on cancer cells |
HDAC3/NCOR (human, recombinant) (Cat. #
SE-515)
HDAC3/NCOR complex displays ~100-fold higher deacetylase activity than isolated HDAC3 |
HDAC6 (human, recombinant) (Cat. #
SE-508)
A tubulin deacetylase, HDAC6 promotes autophagic clearing of huntingtin aggregates, slows HIV1 infection, and promotes invasive motility in tumor cells |
HDAC8 (human, recombinant) (Cat. #
SE-145)
siRNA-knockdown of HDAC8 expression inhibits the growth of several human tumor cell lines, suggesting that HDAC8 activity may be significant in the pathogenesis of solid as well as hematologic tumors |
related products
deacetylase assays |
sirtuin enzymes
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HDAC and sirtuin substrates |
HDAC inhibitors |
HDAC and sirtuin antibodies |
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Deacetylase Assays
BIOMOL has developed the Fluor de Lys(TM) Deacetylase Assay, a versatile
nonradioactive assay for measuring HDAC and sirtuin activity. The assay is compatible with all three classes of HDACs (class I, class II and sirtuins), and a variety of compatible substrates are available
based on acetylated sites found in p53 and histones. |
General assays
Suitable for measuring activity from extracts, immunoprecipitates, recombinant enzymes or whole cells. |
Drug Discovery Assays
Designed for inhibitor screening of the enzyme supplied |
| HDAC Fluorimetric Assay (Cat. # AK-500) |
HDAC8 Drug Discovery Assay (Cat. #
AK-518) |
| HDAC Colorimetric Assay (Cat. # AK-501) |
SIRT1 Drug Discovery Assay (Cat. #
AK-555) |
| HDAC Cellular Assay (Cat. # AK-503) |
SIRT2 Drug Discovery Assay (Cat. #
AK-556) |
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SIRT3 Drug Discovery Assay (Cat. #
AK-557) |
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| Nuclear Receptor Reagents |
Adapalene (Cat. #
GR-111)
A
stable analog of retinoic acid and acts selectively as an agonist at RARbeta and RARgamma. |
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AC-55649 (Cat. #
GR-112)
A potent and subtype selective agonist at RARbeta2 ( EC50=6.9 μM). |
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Aryl Hydrocarbon Receptor (Ahr), rabbit pAb (Cat. #
SA-550)
Species reactibity: mouse, rat; Applications: WB, IP, ChIP
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Western blot analysis of mouse liver extract using the Ahr pAb |
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| Lipid Signaling and Biosynthesis |
Simvastatin (Cat. #
G-244)
HMG-CoA reductase inhibitor. Inhibits the biosynthesis of isoprenoids and cholesterol and prevents small G protein activation |
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Cilastatin sodium (Cat. #
PI-153)
Inhibits the conversion of leukotriene D4 to leukotriene E4 |
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PD-146176 (Cat. #
EI-356)
A potent and selective 15-lipoxygenase inhibitor which lacks significant nonspecific antioxidant properties |
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WEB-2086 (Cat. #
L-137)
The classic PAF receptor antagonist. It inhibits PAF-induced human platelet and neutrophil aggregation in vitro (IC50=0.17 and 0.36 microM respectively).
In vivo WEB-2086 dose dependently inhibits PAF-induced bronchoconstriction, hypotension and lethality |
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| Kinases |
BIOMOL Offers over 115 recombinant kinases!
click here for a complete listing |
CDK5/p25 (human, recombinant) (Cat. # SE-471)
CDK5 is the most abundant CDK in brain and CDK/p25 activity is implicated in Alzheimer's disease pathophysiology
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ERK1 (human, recombinant)(Cat. #
SE-511)
A MAP kinase family member (MAPK3) involved in cell motility, proliferation, differentiation and survival
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JNK1beta2 (human, recombinant) (Cat. #
SE-510)
JNK1 is the major c-Jun kinase after stimulation by inflammatory cytokines and environmental stresses |
MEK1 (human, recombinant) (Cat. #
SE-509)
A dual-specificity kinase that activates ERK1/2 in response to extracellular and intracellular signals |
RAF1 (human, recombinant) (Cat. #
SE-506)
RAF1 functions downstream from the Ras family of GTPases and phosphorylates MEK1 and MEK2 |
p38 (human, recombinant) (Cat. #
SE-499)
A member of the MAP kinase family (MAPK14) and is activated by environmental stresses and some pro-inflammatory cytokines. |
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Request our Compound Libraries Product Guide
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BIOMOL Screen-Well(TM) libraries are focused collections of known active compounds ideal for assay development, receptor de-orphaning and chemical genomics. BIOMOL offers the following collections:
Receptor De-orphaning
Bioactive Lipids
Endocannabinoids
Fatty Acids
Neurotransmitters
Nuclear Receptor Ligands
Orphan Ligands |
Chemical Genomics
ICCB Known Bioactives
Kinase Inhibitors
Ion Channel Ligands
Phosphatase Inhibitors
Protease Inhibitors
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Natural Products
Natural Products
Rare Natural Products |
The Compound Libaries Product Guide contains detailed information on the entire Screen-Well offering. Request your copy today! |
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