Ubiquitons
Ubiquitin is the founding member of a family of structurally conserved proteins, the ubiquitin-like proteins or ‘ubiquitons’. Despite the highly variable sequence homology between these proteins, they all display a structural ubiquitin-like superfold. The attachment of a single ubiquiton, or of varied ubiquitin or SUMO chains, via multi-step cascades, to acceptor proteins is now a widely recognized form of protein modification.




Zomes
The structure of the 20S proteasome, while relatively simple in concept, can have a multiplicity of forms in reality ranging from the ‘constitutive’ form containing only β1, β2, and β5 subunits at one extreme and the ‘inducible’ form containing only β1i, β2i, and β5i at the other.  When these variants interact with the various other recognized complexes (11S activator, 19S regulator, COP9 signalosome (Csn), PA200 activator, PI31) this has the potential to give rise to considerable further compositional complexity. TPPII is an additional complex believed to be responsible for the majority of post-proteasomal peptide processing, in concert with a small family of specific endopeptidases. 

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Ubiquitin, chains and derivatives
Ubiquitin derivatives
Ubiquitin chains
Antibodies to ubiquitin/ubiquitin chains

Ubiquitin and Ubl cascade enzymes
Activating enzymes (E1s)
Antibodies to E1s
Conjugating enzymes (E2s)
Antibodies to E2s
Ligases (E3s) and substrates
De-conjugating enzymes (DUBs, etc.)

Ubiquitin-like proteins (Ubls)
Proteins
Antibodies
Cascade enzymes and substrates

Polyubiquitin-chain binding entities
UBA / related domains / conjugates
Antibodies to UBA domains

Ubl assay systems
Ubiquitinylation kit
SUMOylation kit

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Proteasome
Complexes
Subunit antibodies
Assay systems
Substrates
Inhibitors

COP9 Signalosome
Complex
Subunit antibodies
Inhibitors

TPPII
Complex

Miscellaneous
Cell fractions
Antibodies
Other reagents