BIOMOL Online December 2006
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Cathepsin S Reagents
Cathepsin S is a cysteine protease which is an important drug discovery target due to its involvement in immune system function, rheumatoid arthritis, multiple sclerosis, and cancer. Targets of cathepsin S include MHC Class II-associated invariant chain, laminin-5, amyloid beta peptide, and MBP (myelin basic protein). |
Cathepsin S Drug Discovery Kit (Cat. # AK-431)
The Cathepsin S Drug Discovery Kit is a complete system designed to screen modulators of cathepsin S activity. Included are active cathepsin S enzyme, fluorogenic (Z-VVR-AMC) substrate, assay buffer, and control inhibitor E-64. Enough reagents for 96-assays. |
Cathepsin S (human, recombinant) (Cat. # SE-453)
Cloned from human cDNA as full-length proenzyme, auto-activated by incubation in acetate buffer, and purified. Applications: study of enzyme kinetics, cleave target substrates, and screen for inhibitors.
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Z-VVR-AMC, Fluorogenic Substrate (Cat. # P-199)
Sensitive fluorogenic substrate for cathepsin S and cathepsin L. |
related products
cathepsin assay kits | cathepsin enzymes | cathepsin substrates | cathepsin antibodies | cathepsin inhibitors |
| Cannabinoid Receptor Antibodies |
| The medicinal properties of cannabinoids have been known for centuries and they, together with their endogenous counterparts (endocannabinoids), are known to affect diverse biological processes. Endocannabinoid signaling involves two G protein-coupled receptors, CB1 in the CNS and CB2 in the periphery. Modulators of these receptors are being developed as therapeutics for obesity, pain and neurodegenerative disease. |
Cannabinoid Receptor 1, rabbit pAb (Cat. # SA-551)
Recognizes human and rat CB1. Applications: WB, IHC, ICC. |
Immunolabeling of AtT20 cells transfected with rat CB1, using the CB1 antibody (Cat. # SA-551)
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Cannabinoid Receptor 1, rabbit pAb (Cat. # SA-553)
Recognizes human, rat, mouse, fish, chicken, amphibian, and non-human primate. Applications: WB, IHC, ICC, FACS. |
Immunolabeling of transverse spinal cord sections of E6 chick embryo, using the CB1 antibody (Cat. # SA-553). |
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Cannabinoid Receptor 2, rabbit pAb (Cat. # SA-552)
Recognizes human CB2. Applications: WB, IHC, ICC, IF, FACS. |
Cannabinoid Receptor 2, rabbit pAb (Cat. # SA-554)
Recognizes rat and human CB2. Applications: FACS, ICC. |
Immunolabeling of AtT20 cells transfected with rat CB2, using the CB2 antibody (Cat. # SA-554). |
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| FAAH Substrates and Inhibitors |
| Fatty acid amide hydrolase (FAAH) is an integral membrane enzyme that degrades endogenous cannabinoids, such as anandamide (Cat. # FA-017) and 2-arachidonoylglycerol (Cat. # FA-028), and terminates signaling by these lipid-mediators. The cannabinoid system regulates pain, feeding, motor coordination and memory. Therefore, inhibition of FAAH may provide specific therapeutics for pain, obesity, and neurodegenerative disorders.
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Arachidonoyl-AMC (Cat. # ST-405)
Fluorogenic substrate for fatty acid amide hydrolase (FAAH). |
Decanoyl-p-nitroanilide (Cat. # ST-505)
Colorimetric substrate for FAAH. |
URB-597 (Cat. EI-327)
URB-597 is a potent and selective inhibitor of FAAH. URB-597 has been shown to inhibit FAAH in rat cortical neuron membranes, and in intact neurons with IC50 values of 4.6 nM and 0.5 nM respectively. The compound has also been shown to have anxiolytic effects in rats (ID50 = 0.15 mg/kg).URB-597 does not interfere with the binding of anandamide to the CB1 and CB2 receptors. |
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endocannabinoids | cannabinoid drugs | cannabinoid metabolism | cannabinoid receptor antibodies |
| 2-Pore Domain Potassium Channel Antibodies |
2-Pore (2P) domain K+ channels comprise a family that includes 15 members. These channels show little
time or voltage dependence and are considered to be "leaky" or "background" K+ channels, generating background currents which help set the membrane resting potential and cell excitation. The K2P channels have a signature topology that includes four transmembrane domains and two pore domains with intracellular N- and C-termini. K2P channels are regulated by diverse physical and chemical stimuli including temperature, pH, mechanical stretch, inhalation anesthetics, etc. |
K2P1.1 (TWICK1, KCNK1), rabbit pAb (Cat. # SA-568)
Species reactivity: human, rat and mouse. Applications: WB, IHC. |
Immunolabeling of rat cerebellum with the K2P1.1 antibody |
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K2P2.1 (TREK1, KCNK2), rabbit pAb (Cat. # SA-569)
Species reactivity: human and rat. Applications: WB. |
K2P3.1 (TASK1, KCNK3), rabbit pAb (Cat. # SA-570)
Species reactivity: human and rat. Applications: WB, IHC. |
K2P4.1 (TRAAK, KCNK4), rabbit pAb (Cat. # SA-571)
Species reactivity: rat. Applications: WB, IHC. |
Immunolabeling of rat cerebellum with the K2P4.1 antibody |
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K2P5.1 (TASK2, KCNK5), rabbit pAb (Cat. # SA-572)
Species reactivity: rat. Applications: WB, IHC. |
K2P6.1 (TWIK2, TOSS, KCNK6), rabbit pAb (Cat. # SA-573)
Species reactivity: rat. Applications: WB. |
K2P9.1 (TASK3, KCNK9), rabbit pAb (Cat. # SA-574)
Species reactivity: human and rat. Applications: WB. |
K2P10.1 (TREK2, KCNK10), rabbit pAb (Cat. # SA-575)
This antibody recognizes human and rat. Applications: WB, IHC. |
Immunofluorescence labeling of rat cerebellum using the K2P10.1 antibody |
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ion channel antibodies | potassium channel modulators | ion channel reagents |
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