BIOMOL Online February 2007
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JNK Reagents
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The Jun N-terminal kinases (JNKs), also known as stress-activated
protein kinases (SAPKs), are known to be activated by cell stress-inducing stimuli such as heat shock, UV irradiation,
hyperosmolarity, and ischemia/reperfusion injury, and by specific cell surface receptors. JNK family kinases
phosphorylate a number of nuclear targets and regulate multiple biological processes that include embryonic
morphogenesis, apoptosis, thymocyte development and activation, and cell proliferation.
BIOMOL offers a broad selection of active JNK enzymes, specific inhibitors, substrates and
phosphospecific antibodies for studying the JNK pathway. |
JNK Inhibitors and Activators
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NEW - L-JNK inhibitor 1 (Cat. # EI-354)
A cell-permeable peptide that inhibits the interaction between JNK (JNK-1, -2 and –3) and its substrate (in vitro IC50 ~ 1 microM). |
NEW - D-JNK Inhibitor 1 (Cat. #
EI-355)
Similar to L-JNK inhibitor 1 (above), but the D-stereoisomer is less readily degraded than the L-stereoisomer (Cat. # EI-354) when administered to experimental animals.
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SP600125 (Cat. #
EI-305)
A novel potent JNK1, -2, and -3 inhibitor (IC50=0.11 microM)
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Anisomycin (Cat. #
ST-102)
Activates JNK/SAPKs, but not ERKs, leading to the phosphorylation of S6, histone H3 and HMG-14, and the induction of the immediate-early genes c-fos and c-jun. |
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| JNK Enzymes |
JNK2 (human, recombinant) (Cat. #
SE-464
)
Active, full-length JNK2. Activated by coexpression with MKK7. |
JNK3 (human, recombinant) (Cat. #
SE-465)
Active, full-length JNK3.
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| JNK Substrates |
c-Jun (1-79), JNK Substrate (rat, recombinant) (Cat. #
SE-151)
GST-fusion protein of the c-Jun (1-79) activation domain, expressed in E. coli. |
Activating Transcription Factor 2 (human, recombinant) (Cat. #
SE-261)
Human recombinant ATF2, corresponding to amino acids 19-99, expressed in E. coli. |
p53 (human, recombinant), GST-tagged (Cat. #
FW9370)
GST-tagged, full-length human p53 expressed in E. coli.
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| JNK-related Antibodies |
JNK1, rabbit pAb (Cat. #
SA-267)
Species reactivity: human and rat. Applications: WB. |
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JNK1&2 (pT183, pY185), rabbit pAb (Cat. #
SA-272)
Species reactivity: human and rat. Applications: WB, IHC. |
MEK7, mouse mAb clone 3F5 (Cat. #
SA-347)
Species reactivity: human MEK7. Applications: WB, ELISA. |
HEK 293 cells were treated with ultraviolet irradiation (UV) and extracts were immunoblotted with anti-JNK1/2 [pTpY183/185] (a) or anti-JNK1 (b). |
ATF2 (pT71), rabbit pAb (Cat. #
SA-399)
Threonine 71, along with threonine 69, is phosphorylated by JNK and is essential for ATF2 transcriptional activity. Species reactivity: human. Applications: WB. |
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| HCN Channel Antibodies |
The hyperpolarization-activated
cyclic nucleotide-gated channel family (HCN), comprised of four homologous members, generates
hyperpolarization-activated cation currents (Ih) in the heart and the brain. Ih currents play a crucial role in controlling
electrical pacemaker activity, contributing to biological processes such as heartbeat, sleep-wake cycle and synaptic plasticity. Each HCN subunit consists of six transmembrane (TM) domains, a pore region between TM5-TM6 and a cyclic nucleotide binding domain
in the cytoplasmic C-terminus. The HCN subunits can form functional homomers and can also co-assemble into functional heteromers. HCN1-4 differ in their speed of activation and the extent to which they are modulated by cAMP. HCN1 is the fastest
channel, followed by HCN2, HCN3 and HCN4. Recently this family of channels has been implicated in a newly recognized mechanism for chronic pain.
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HCN1, rabbit pAb (Cat. #
SA-597)
Species reactivity: rat, mouse and human. Applications: WB, IHC.
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HCN2, rabbit pAb (Cat. #
SA-598)
Species reactivity: rat and human. Applications: WB, IHC. |
HCN3, rabbit pAb (Cat. #
SA-599)
Species reactivity: rat. Applications: WB. |
HCN4, rabbit pAb (Cat. #
SA-600)
Species reactivity: rat and mouse. Applications: WB, IHC. |
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| Glutamate Receptor Agonist and Antibodies |
AMN082 (Cat. # EA-148)
Potent and selective agonist at mGluR7 acting at an allosteric site.
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GluR1 (pS831), rabbit pAb (Cat. # SA-533)
Species reactivity: human, mouse and rat. Applications: WB.
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GluR1 (pS845), rabbit pAb (Cat. #
SA-534)
Species reactivity: human, mouse and rat. Applications: WB.
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Request our Neuroscience Antibodies Product Guide
This guide details over 200 highly characterized antibodies for neuroscience
research. These antibodies complement an offering of neurotransmitters, ion channel modulators and drugs available online and in our catalog.
| Includes antibodies to: |
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| Neurodegenerative Disease |
Neurotransmitters |
| Neurotransmitter Biosynthesis Enzymes |
Neurofilament Proteins |
| Ion Channels |
Neurotransmitter Receptors |
| Exocytosis and Vesicle Trafficking Proteins |
Ephrin Receptors |
| Neurotransmitter Transporters |
and more |
| Request your copy today |
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| VEGFR Inhibitors and Enzymes |
ZM-306416 (Cat. #
EI-353)
VEGFR tyrosine kinase inhibitor. Inhibits KDR (IC50= 100 nM ) and Flt (IC50= 2 microM) tyrosine kinases. |
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SU 4312 (Cat. #
EI-306)
A potent and selective inhibitor of VEGFR-2 (Flk-1, KDR). It displays a 100-fold greater potency for the unactivated form of the kinase (Ki=20 nM) compared to the activated form (Ki=4 microM). |
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Flt1 (human, recombinant) (Cat. #
SE-445)
Active Flt1, amino acids 783 to end, expressed in insect cells. |
VEGFR2 (human, recombinant) (Cat. # SE-404)
Active VEGFR2, amino acids 805-1356. |
related products
tyrosine kinases |
kinase enzymes |
kinase inhibitors |
serine/threonine kinases |
phosphospecific antibodies |
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