BIOMOL International, LP

April 2006


	Featured Products Endocannabinoid reagents N-Arachidonoyl-L-serine FAAH substrate and inhibitor \| MAG lipase inhibitors Endocannabinoid Library New Products Protease antibodies \| PPAR ligands Kinase Inhibitor Library

Featured Products

Rimonabant (Credit: Sanofi-Aventis SA)

Endocannabinoid Reagents

Endocannabinoids, endogenous ligands of the cannabinoid receptors, play important roles in many biological processes including the regulation of appetite, pain and addictive behaviors. The CB1 receptor antagonist Rimonabant (SR141716, Acomplia) from Sanofi-Aventis is currently awaiting FDA approval for obesity (inquire).

N-Arachidonoyl-L-Serine (Cat. # FA-037) A recently discovered endocannabinoid isolated from bovine brain, which may be an endogenous agonist for a putative novel CB receptor.
URB-754 (Cat. # EI-349) Potent and selective inhibitor of MAG lipase which selectively raises levels of 2-arachidonoylglycerol.
URB-602 (Cat. # EI-348) Selectively inhibits MAG lipase (IC₅₀=28microM) via a noncompetitive mechanism.
URB-597 (Cat. # EI-327) Potent and selective inhibitor of the enzyme fatty acid amide hydrolase (FAAH; IC₅₀'s=0.5-5 nM), which is involved in the hydrolysis of endogenous cannabinoids such as anandamide (Cat.# FA-017).
Arachidonoyl-AMC (Cat. # ST-504) Fluorogenic substrate for fatty acid amide hydrolase (FAAH). This substrate is the basis for a simple, selective and sensitive assay for FAAH which is amenable to high-throughput screening.
VDM-11 (Cat. # CR-111) A potent and selective inhibitor of the anandamide membrane transporter (AMT). Displays little activity at TRPV1 channels or CB1 and CB2 receptors.

Endocannabinoid Library (Cat. # 2801)
The Screen-Well^TM Endocannabinoid Library contains 60 compounds with defined, putative, potential or speculative activity at cannabinoid (CB) and vanilloid (VR) receptors. The library is an array of 10 different fatty acids and 6 different polar head groups. Ligands are supplied dissolved in biocompatible solvents at 1 mM and aliquoted into deep-well plates at 500 µl per well. The library is a rich source of ligands for receptor de-orphaning. For structure files and pricing contact techserv@biomol.com.

For related products:

Cannabinoids | Endocannabinoids | Cannabinoid drugs | Cannabinoid metabolism

New Products

Protease Antibodies

ADAM12 (Catalytic Domain), Rabbit pAb (Cat. # SA-470) Recognizes all latent and active forms of human ADAM12. Applications: WB.	Western blot analysis of human renal carcinoma lysate using Anti-ADAM12, showing two glycosylated, processed forms of ADAM12
ADAMTS13, Rabbit pAb (Cat. # SA-473) Recognizes latent and active forms of human, mouse and rat ADAMTS13. Applications: WB.
BACE1, Rabbit pAb (Cat. # SA-465) Recognizes human, mouse, and rat BACE1 pro- and mature forms, but not BACE2. Applications: WB.
BACE2, Rabbit pAb (Cat. # SA-466) Recognizes human, mouse, and rat BACE2 pro- and mature forms, but not BACE1. Applications: WB.
FAPalpha, Rabbit pAb (Cat. # SA-472) Recognizes human, mouse and rat FAPalpha, including the naturally-occurring soluble catalytic domain (other species not yet tested). Applications: WB.
Furin, Rabbit pAb (Cat. # SA-471) Recognizes latent, active, and soluble forms of human, mouse and rat furin. Applications: WB.
MMP12 (C-terminus), Rabbit pAb (Cat. # SA-467) Recognizes latent (54 kDa), active (45 kDa), and intermediate forms of mouse and rat MMP-12. Does not cross react with other MMPs. Applications: WB.
Neutrophil Elastase, Rabbit pAb (Cat. # SA-469) Recognizes human neutrophil elastase but not cathepsin G, myeloperoxidase, nor proteinase 3. Applications: WB, ELISA.

For related products:

PPAR Ligands

BADGE (Cat. # GR-244) PPARγ antagonist.
T0070907 (Cat. # GR-212) Potent and selective PPARγ antagonist. T0070907 blocks PPARγ function in both cell-based reporter gene and adipocyte differentiation assays.

For related products:

Nuclear Receptors | PPAR Ligands | PPAR Antibodies

Kinase Inhibitor Library

The Screen-Well^TM Kinase Inhibitor Library contains 80 known kinase inhibitors of well-defined activity. Inhibitors are supplied dissolved in DMSO at 10 mM and aliquoted into deep-well plates at either 100 or 500 microliters per well. The library is an ideal tool for chemical genomics, assay development and other pharmacological applications.

Includes inhibitors of these important kinases:

BTK	EGFR	JAK	MLCK	PKC
CaM Kinase II	GSK	JNK	PDGFR	RAF
CDK	IKK	MAPK	PI 3-Kinase	SAPK
CKI & II	Insulin/IGF Receptors	MEK	PKA	Src-family
VEGF	and more . . .

Cat. # 2832

For structure files and pricing contact techserv@biomol.com

For related products:

Compound Libraries | Kinase Inhibitors | Recombinant Kinases | Ser/Thr Kinases | Tyr Kinases

The BIOMOL 9th Edition Catalog/Handbook - Now available
The BIOMOL Catalog/Handbook goes beyond the usual dictionary listing of reagents. Reagents are introduced within specific signal transduction pathways organized by their respective function in the signaling cascade. Useful tables, application notes and up-to-date literature references for each reagent are also included. Request your copy today.
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